Department of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Ga.
Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, Atlanta, Ga.
J Thorac Cardiovasc Surg. 2014 Feb;147(2):666-71. doi: 10.1016/j.jtcvs.2013.09.053. Epub 2013 Nov 16.
Patients with congenital heart disease are frequently surviving into adulthood, and many of them will require surgery. Currently, there is no validated risk scoring system for adult congenital heart surgery, and predicting outcomes in these patients is challenging. Our objective was to determine if commonly used pediatric congenital heart disease surgery risk scores are also applicable to adults.
Four hundred fifty-eight adult (age ≥ 18 years) operations involving cardiac surgery for congenital heart disease between 2000 and 2010 at a single institution were studied retrospectively. The pediatric scores evaluated were the Risk Adjustment for Congenital Heart Surgery (RACHS-1) score, the Aristotle Basic Score, and the Society of Thoracic Surgery-European Association for Cardio-Thoracic Surgery (STAT) Congenital Heart Surgery Mortality score. Receiver operating characteristic (ROC) curves were generated to assess the ability of the scoring systems to predict mortality, major adverse events (stroke, renal failure, prolonged ventilation, prolonged coma, deep sternal infection, reoperation, and operative mortality), and prolonged length of stay (>7 days).
Of 458 operations, there were 16 (3%) deaths, 94 (21%) major adverse events, and 90 (20%) prolonged lengths of stay. Four hundred thirty (94%) of the operations were included in all 3 scoring systems and the ROC analysis. For mortality, areas under the ROC curve were 0.91, 0.91, and 0.65 for the Aristotle, STAT, and RACHS-1 scores, respectively. For major adverse event, areas under the ROC curves were 0.81, 0.76, and 0.61 for the Aristotle, STAT, and RACHS-1 scores, respectively. For prolonged length of stay, areas under the ROC curve were 0.82, 0.76, and 0.61 for the Aristotle, STAT, and RACHS-1 scores, respectively.
Pediatric risk scoring systems such as Aristotle, STAT, and RACHS-1 offer prognostic value in adults undergoing congenital heart surgery. The scores are predictive of mortality, major adverse events, and prolonged lengths of stay. The STAT and Aristotle systems fared best.
患有先天性心脏病的患者经常能存活到成年,其中许多人需要接受手术。目前,尚无经过验证的成人先天性心脏病手术风险评分系统,预测这些患者的结局具有挑战性。我们的目的是确定常用的儿科先天性心脏病手术风险评分系统是否也适用于成人。
回顾性研究了 2000 年至 2010 年在一家单中心进行的 458 例成人(年龄≥18 岁)心脏手术治疗先天性心脏病的病例。评估的儿科评分包括先天性心脏手术风险调整评分(RACHS-1)评分、阿里斯托特基本评分和胸外科医师学会-欧洲心胸外科协会(STAT)先天性心脏病手术死亡率评分。生成受试者工作特征(ROC)曲线以评估评分系统预测死亡率、主要不良事件(中风、肾衰竭、通气延长、昏迷延长、深部胸骨感染、再次手术和手术死亡率)和住院时间延长(>7 天)的能力。
在 458 例手术中,有 16 例(3%)死亡,94 例(21%)发生主要不良事件,90 例(20%)住院时间延长。430 例(94%)手术均包含在所有 3 种评分系统和 ROC 分析中。死亡率的 ROC 曲线下面积分别为阿里斯托特、STAT 和 RACHS-1 评分的 0.91、0.91 和 0.65。主要不良事件的 ROC 曲线下面积分别为阿里斯托特、STAT 和 RACHS-1 评分的 0.81、0.76 和 0.61。住院时间延长的 ROC 曲线下面积分别为阿里斯托特、STAT 和 RACHS-1 评分的 0.82、0.76 和 0.61。
儿科风险评分系统(如阿里斯托特、STAT 和 RACHS-1)在接受先天性心脏手术的成年人中具有预后价值。这些评分可预测死亡率、主要不良事件和住院时间延长。STAT 和阿里斯托特系统表现最佳。