Walsh Bill, Mueller Brigitte, Roche S Lucy, Alonso-Gonzalez Rafael, Somerset Emily, Sano Minako, Villagran Schmidt Milca, Hickey Edward, Barron David, Heggie Jane
Department of Anesthesia and Pain Medicine, Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, Ontario, Canada.
Ted Rogers Computational Program, Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, Ontario, Canada.
JTCVS Open. 2023 May 2;14:188-204. doi: 10.1016/j.xjon.2023.04.016. eCollection 2023 Jun.
A quality improvement initiative was introduced to the adult congenital cardiac surgery program at Toronto General Hospital in January 2016. A dedicated Adult Congenital Anesthesia and intensive care unit team was introduced within the cardiac group. The use of factor concentrates was introduced. The study compares perioperative mortality, adverse events, and transfusion burden before and after this process change.
We performed a retrospective analysis of all adult congenital cardiac surgeries from January 2004 to July 2019. Two groups were analyzed: patients undergoing operation before and after 2016. The primary outcome was in-hospital mortality. One-year mortality and prevalence of key morbidities were analyzed as secondary outcomes. A separate analysis looked at patients who had and had not attended an anesthesia-led preassessment clinic.
In-hospital mortality was significantly reduced in patients undergoing operation after 2016 (1.1% vs 4.3%, = .003) despite a higher risk profile. One-year mortality (1.3% vs 5.8%, = .003) and ventilation times (5.5 hours [3.4-13.0] vs 6.3 hours [4.2-16.2], = .001) were also reduced. The incidence of stroke and renal failure was similar between groups. Blood product exposure was comparable, but the incidence of chest reopening decreased (1.8% vs 4.8%, = .022), despite more patients with multiple previous chest wall incisions, on anticoagulation, and with more complex cardiac anatomy. There were no significant outcome differences between those who did or did not attend the preassessment clinic.
Both in-hospital and 1-year mortality were significantly reduced after the introduction of a quality improvement program, despite a higher risk profile. Blood product exposure remained unchanged, but there were less chest reopenings.
2016年1月,多伦多综合医院的成人先天性心脏手术项目引入了一项质量改进举措。在心脏团队中引入了一个专门的成人先天性麻醉和重症监护病房团队。引入了凝血因子浓缩剂的使用。本研究比较了这一流程改变前后的围手术期死亡率、不良事件和输血负担。
我们对2004年1月至2019年7月期间所有成人先天性心脏手术进行了回顾性分析。分析了两组:2016年之前和之后接受手术的患者。主要结局是住院死亡率。将1年死亡率和主要并发症的患病率作为次要结局进行分析。另一项分析针对参加和未参加麻醉主导的术前评估门诊的患者。
尽管风险更高,但2016年之后接受手术的患者住院死亡率显著降低(1.1%对4.3%,P = 0.003)。1年死亡率(1.3%对5.8%,P = 0.003)和通气时间(5.5小时[3.4 - 13.0]对6.3小时[4.2 - 16.2],P = 0.001)也有所降低。两组之间中风和肾衰竭的发生率相似。血液制品暴露情况相当,但再次开胸的发生率降低(1.8%对4.8%,P = 0.022),尽管有更多患者有多次既往胸壁切口、正在接受抗凝治疗且心脏解剖结构更复杂。参加或未参加术前评估门诊的患者在结局方面没有显著差异。
尽管风险更高,但在引入质量改进项目后,住院死亡率和1年死亡率均显著降低。血液制品暴露情况保持不变,但再次开胸的情况减少。