Medical College of Wisconsin and the Herma Heart Center at the Children's Hospital of Wisconsin, Milwaukee, Wis.
Medical College of Wisconsin and the Herma Heart Center at the Children's Hospital of Wisconsin, Milwaukee, Wis; Division of Critical Care in the Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wis.
J Thorac Cardiovasc Surg. 2014 Feb;147(2):672-7. doi: 10.1016/j.jtcvs.2013.09.055. Epub 2013 Nov 16.
To evaluate outcomes of systemic to pulmonary artery shunts (SPS) in patients weighing less than 3 kg with regard to shunt type, shunt size, and surgical approach.
Patients weighing less than 3 kg who underwent modified Blalock-Taussig or central shunts with polytetrafluoroethylene grafts at our institution from January 1, 2000, to May 31, 2011, were reviewed. Patients who had undergone other major concomitant procedures were excluded from the analysis. Primary outcomes included mortality (discharge mortality and mortality before next planned palliative procedure or definitive repair), cardiac arrest and/or extracorporeal membrane oxygenation (ECMO), and shunt reintervention.
In this cohort of 80 patients, discharge survival was 96% (77/80). Postoperative cardiac arrest or ECMO occurred in 6/80 (7.5%), and shunt reintervention was required in 14/80 (17%). On univariate analysis, shunt reintervention was more common in patients with 3-mm shunts (11/30, 37%) compared with 3.5-mm (2/36, 6%) or 4-mm shunts (1/14, 7%) (P < .003). There were no statistically significant associations between shunt type, shunt size, or surgical approach and cardiac arrest/ECMO or mortality. Multiple logistic regression demonstrated that a shunt size of 3 mm (P = .019) and extracardiac anomaly (P = .047) were associated with shunt reintervention, whereas no variable was associated with cardiac arrest/ECMO or mortality.
In this high-risk group of neonates weighing less than 3 kg at the time of SPS, survival to discharge and the next planned surgical procedure was high. Outcomes were good with the 3.5- and 4-mm shunts; however, shunt reintervention was common with 3-mm shunts.
评估体肺动脉分流术(SPS)在体重小于 3 公斤的患者中的疗效,重点关注分流类型、分流大小和手术入路。
对 2000 年 1 月 1 日至 2011 年 5 月 31 日期间在我院接受改良 Blalock-Taussig 分流术或中心分流术联合聚四氟乙烯移植物的体重小于 3 公斤的患者进行回顾性分析。排除同时进行其他主要伴随手术的患者。主要结局包括死亡率(出院死亡率和下次计划姑息性手术或确定性修复前死亡率)、心脏骤停和/或体外膜氧合(ECMO)以及分流再干预。
在这 80 例患者的队列中,出院存活率为 96%(77/80)。术后发生心脏骤停或 ECMO 的有 6/80(7.5%),需要分流再干预的有 14/80(17%)。单因素分析显示,3mm 分流器(11/30,37%)比 3.5mm(2/36,6%)或 4mm 分流器(1/14,7%)的分流再干预更为常见(P<0.003)。分流类型、分流大小或手术入路与心脏骤停/ECMO 或死亡率之间无统计学显著关联。多因素逻辑回归显示,分流器大小为 3mm(P=0.019)和心脏外异常(P=0.047)与分流再干预有关,而无其他变量与心脏骤停/ECMO 或死亡率相关。
在 SPS 时体重小于 3 公斤的这一高危新生儿组中,出院生存率和下一次计划手术的生存率较高。3.5mm 和 4mm 分流器的结果良好,但 3mm 分流器的分流再干预较常见。