通过有机催化级联反应方法进行 3,4-稠合吲哚的不对称合成。
Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach.
机构信息
Department of Industrial Chemistry "Toso Montanari", School of Science, University of Bologna, V. Risorgimento 4, 40136, Bologna, Italy.
出版信息
Chem Commun (Camb). 2014 Jan 14;50(4):445-7. doi: 10.1039/c3cc47841f.
PMID:24252947
Abstract
Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities and as single diastereoisomers.
摘要
4-位具有迈克尔受体的吲哚与烯醛发生了有机催化的对映选择性级联反应。通过仔细优化反应参数克服了这些底物固有的低反应性，以良好的收率、优异的对映选择性和单一非对映异构体得到了 3,4-环稠合吲哚。
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