Department of Psychiatry, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, 105-8471, Japan,
J Neural Transm (Vienna). 2014 Apr;121(4):433-41. doi: 10.1007/s00702-013-1121-y. Epub 2013 Nov 20.
In the present study, we examined whether neuropsychiatric symptoms were correlated with plasma brain-derived neurotrophic factor (BDNF) levels as a state marker or were associated with the BDNF polymorphism Val66Met in patients with amnestic mild cognitive impairment (A-MCI) or Alzheimer disease (AD). One hundred and seventy-six outpatients with AD (n = 129) or A-MCI (n = 47) were selected and their plasma BDNF concentrations measured. Next, we investigated the correlation between the plasma BDNF level and the Behavioral Pathology in Alzheimer Disease (Behave-AD) subscale scores, which reflect neuropsychiatric symptoms. We also compared the plasma BDNF level and the Behave-AD subscale scores among the BDNF Val66Met genotypic groups. Among the seven Behave-AD subscale scores, aggressiveness was positively correlated with the plasma BDNF level (ρ = 0.237, P < 0.005), but did not differ significantly among the three BDNF Val66Met genotypic groups. The Behave-AD total and other subscale scores did not differ significantly among the BDNF Val66Met genotypic groups and were not associated with the plasma BDNF level. Moreover, the plasma BDNF level did not differ significantly among the three BDNF Val66Met genotypic groups or between patients with A-MCI and those with AD. The plasma BDNF level was robustly correlated with aggressiveness, implying that the plasma BDNF level might be useful as a behavioral state marker in patients with AD or A-MCI.
在本研究中，我们检查了神经精神症状是否与作为状态标志物的血浆脑源性神经营养因子（BDNF）水平相关，或者与遗忘型轻度认知障碍（A-MCI）或阿尔茨海默病（AD）患者的 BDNF Val66Met 多态性相关。我们选择了 176 名 AD（n=129）或 A-MCI（n=47）门诊患者，测量了他们的血浆 BDNF 浓度。接下来，我们研究了血浆 BDNF 水平与反映神经精神症状的阿尔茨海默病行为病理（Behave-AD）亚量表评分之间的相关性。我们还比较了 BDNF Val66Met 基因型组之间的血浆 BDNF 水平和 Behave-AD 亚量表评分。在七个 Behave-AD 亚量表评分中，攻击性与血浆 BDNF 水平呈正相关（ρ=0.237，P<0.005），但在三个 BDNF Val66Met 基因型组之间无显著差异。Behave-AD 总分和其他亚量表评分在 BDNF Val66Met 基因型组之间无显著差异，与血浆 BDNF 水平无关。此外，三个 BDNF Val66Met 基因型组之间以及 A-MCI 患者与 AD 患者之间的血浆 BDNF 水平无显著差异。血浆 BDNF 水平与攻击性呈强相关性，这表明血浆 BDNF 水平可能是 AD 或 A-MCI 患者行为状态标志物的有用指标。
