Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Int J Med Sci. 2012;9(9):772-7. doi: 10.7150/ijms.5063. Epub 2012 Oct 24.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin which modulates neuronal survival and proliferation. Recently, plasma BDNF is associated with inflammatory conditions. The present study was to investigate the changes of the plasma BDNF level in hemodialysis patients and to evaluate the relationship between the plasma BDNF and uremic inflammation.
We measured the plasma BDNF, serum IL-2, IL-4, IFN-γ and TNF-α in hemodialysis patients and control subjects. In addition, we investigated the associations of the plasma BDNF with clinical or biochemical parameters.
The plasma BDNF level was significantly higher in hemodialysis patients than in the control subjects (median, 312.3 vs. 630.3 pg/ml, p < 0.05). In subgroup analysis, hemodialysis patients with diabetes showed higher values of the plasma BDNF than the patients without diabetes. However, there were no significant differences in age and gender subgroups of the hemodialysis patients. The logBDNF was positively correlated with hs-CRP and IFN-γ, and negatively correlated with serum albumin. In multivariate regression analysis, the logBDNF was independently associated with the presence of diabetes (β-coefficient = 0.399, p = 0.041) and IFN-γ (β-coefficient = 0.538, p = 0.003).
The plasma BDNF may increase in hemodialysis patients, and more prominently in the patients with diabetes. Furthermore, the plasma BDNF might reflect inflammatory condition in hemodialysis patients.
脑源性神经营养因子（BDNF）是一种神经营养因子，可调节神经元的存活和增殖。最近，血浆 BDNF 与炎症状态有关。本研究旨在探讨血液透析患者血浆 BDNF 水平的变化，并评估血浆 BDNF 与尿毒症炎症之间的关系。
我们测量了血液透析患者和对照组的血浆 BDNF、血清 IL-2、IL-4、IFN-γ 和 TNF-α。此外，我们还研究了血浆 BDNF 与临床或生化参数的关系。
血液透析患者的血浆 BDNF 水平明显高于对照组（中位数，312.3 vs. 630.3 pg/ml，p < 0.05）。在亚组分析中，糖尿病血液透析患者的血浆 BDNF 值高于非糖尿病患者。然而，在血液透析患者的年龄和性别亚组中，差异无统计学意义。logBDNF 与 hs-CRP 和 IFN-γ 呈正相关，与血清白蛋白呈负相关。在多元回归分析中，logBDNF 与糖尿病的存在独立相关（β系数=0.399，p=0.041）和 IFN-γ（β系数=0.538，p=0.003）。
血液透析患者的血浆 BDNF 可能会增加，尤其是糖尿病患者。此外，血浆 BDNF 可能反映血液透析患者的炎症状态。
