环孢菌素对大鼠微量元素组织分布的修饰。
Modification of tissue distribution of trace elements by cyclosporin in rats.
机构信息
Laboratoire de Pharmacologie, C.H.U., 49033, Angers Cedex, France.
出版信息
Biol Trace Elem Res. 1986 Dec;11(1):13-7. doi: 10.1007/BF02795518.
PMID:24254498
Abstract
Cyclosporin-induced hypomagnesaemia, as observed in patients, could also be induced in rats by intramuscular administration of the drug (20 mg/kg/d) for 12 d. moreover, cyclosporin administration induced modifications in the concentrations of other elements in tissues, particularly an increase in Mg, Cu, and Zn in the thymus and an increase in Mo in the spleen and Sr in the liver.
摘要
环孢素诱导的低镁血症，如在患者中观察到的，也可通过肌肉内给予该药物（20mg/kg/d）12 天诱导在大鼠中发生。此外，环孢素给药诱导组织中其他元素浓度的改变，特别是在胸腺中镁、铜和锌增加，以及在脾脏中钼和在肝脏中锶增加。
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