Institut für Experimentalphysik Ill, Ruhr-Universität Bochum, D-4630, Bochum 1, FRG.
Biol Trace Elem Res. 1987 Apr;12(1):33-44. doi: 10.1007/BF02796664.
The capability of PIXE analysis to simultaneously detect trace elements with Z≥14, with a high power of detection, can be exploited in biomedical research if the diameter of the proton beam is reduced to micrometer dimensions. In this case, trace analyses of small particles or small parts of a larger specimen are rendered possible without deteriorating the detection limits of PIXE. The measurements yield a completely new type of information on the biological microstructure. In order to fully utilize the abilities of the combined method, however, sample preparation techniques, and irradiation procedures have to be adapted to each analysis problem. Examples of application of the Bochum Proton Microprobe will be used to demonstrate how and to what extent this can be achieved for different types of biomedical problems.
如果将质子束的直径减小到微米尺寸，PIXE 分析的能力——同时检测 Z≥14 的微量元素，具有很高的检测能力——可以在生物医学研究中得到利用。在这种情况下，可以在不降低 PIXE 检测限的情况下对小颗粒或较大样本的小部分进行痕量分析。这些测量为生物微观结构提供了一种全新的信息类型。然而，为了充分利用组合方法的能力，必须根据每个分析问题来调整样品制备技术和辐照程序。将使用波鸿质子微探针的应用实例来说明如何以及在何种程度上可以针对不同类型的生物医学问题实现这一目标。
