正常和缺锌条件下大鼠脑亚细胞组分中(65)Zn 的摄取和周转率。

Uptake and turnover of(65)Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions.

机构信息

Department of Radiochemistry, Interuniversity Reactor Institute, Mekelweg 15, 2629 JB, Delft, The Netherlands.

出版信息

Biol Trace Elem Res. 1987 Oct;14(1-2):127-41. doi: 10.1007/BF02795603.

Abstract

After a single injection,(65)Zn is slowly taken up by the brain of the rat to a maximum after 7 d, followed by a turnover phase, with a half-time of about 3 wk. In the brain of rats on a zinc-deficient diet, the(65)Zn content in the brain continued to increase up to 30 d after the injection.The uptake and turnover phases in six different subcellular fractions of the brain showed a pattern similar to that of the whole brain in both the control and zinc-deficient rats. There was no internal redistribution of(65)Zn in the brain under conditions of progressive zinc deficiency.The results are discussed in a model for zinc homeostasis in the brain.

摘要

一次注射后，（65）锌被大鼠的大脑缓慢吸收，7 天后达到最大值，随后进入一个半衰期约为 3 周的转换期。在缺锌饮食的大鼠的大脑中，（65）锌的含量在注射后 30 天内持续增加。大脑六个不同亚细胞部分的摄取和转换阶段在对照组和缺锌组大鼠中与整个大脑的模式相似。在逐渐缺锌的情况下，大脑中的（65）锌没有重新分布。这些结果在大脑中锌稳态的模型中进行了讨论。