Gordon E F, Bond J T, Gordon R C, Denny M R
Physiol Behav. 1982 May;28(5):893-7. doi: 10.1016/0031-9384(82)90210-4.
Zinc deficiency was induced in 35 and 300 day-old male Holtzman rats. Group ZDA was fed ad lib a diet deficient in zinc (1 ppm), ZSP controls were pair-fed a diet supplemented with zinc (50 ppm) and ZSA controls were fed ad lib a diet supplemented with zinc (50 ppm). Physical status and six open-field behaviors were evaluated. Food intake, body weight and plasma zinc concentrations were significantly reduced in both age groups. Expanded use of the open-field revealed significantly lower latencies to explore the novel environment and significantly lower ambulation scores in the young and older zinc deficient rats. Older rats spent significantly less time grooming than their controls. Rearing was significantly less in young zinc deficient rats and "kangaroo-like" posture was evident. Young rats made deficient during critical periods of growth and development, were at greater risk for most parameters tested, compared to the older deficient rats. These rats do demonstrate, however, that feeding low-zinc diets to older, fully developed animals results in significant physical and behavioral impairment.
在35日龄和300日龄的雄性霍尔兹曼大鼠中诱发锌缺乏。ZDA组随意进食锌缺乏（1 ppm）的饮食，ZSP对照组配对进食补充锌（50 ppm）的饮食，ZSA对照组随意进食补充锌（50 ppm）的饮食。评估身体状况和六种旷场行为。两个年龄组的食物摄入量、体重和血浆锌浓度均显著降低。在旷场中，幼年和老年缺锌大鼠探索新环境的潜伏期显著延长，行走得分显著降低。老年大鼠梳理毛发的时间明显少于其对照组。幼年缺锌大鼠的竖毛行为明显减少，且出现“袋鼠样”姿势。与老年缺锌大鼠相比，在生长和发育关键期缺锌的幼年大鼠在大多数测试参数上风险更高。然而，这些大鼠确实表明，给成年、发育完全的动物喂食低锌饮食会导致明显的身体和行为损伤。
