雄性大鼠肾脏铜浓度的品系差异。

Strain differences in kidney copper concentrations of male rats.

机构信息

Department of Pathology, Faculty of Veterinary Science, State University, Utrecht, The Netherlands.

出版信息

Biol Trace Elem Res. 1987 Dec;14(3):217-23. doi: 10.1007/BF02795688.

Abstract

The copper concentrations of the kidneys of male rats of six inbred (BN, F344, LEW, SHR, WAG/Cpb, and WAG/Rij) and one random-bred Wistar strain were determined.In inbred rats the mean concentration varied between strains and ranged from 7.10 μg/g for F 344 to 23.48 μg/g for WAG/Cpb. The calculated coefficient of genetic determination (g(2)) was 0.88. A remarkable discrepancy was found between the two WAG inbred strains; the WAG/Cpb had a 2.5 times higher kidney Cu concentration than the WAG/Rij.Kidney Cu concentrations of random-bred rats varied considerably; the coefficient of variation of the means was 28 and 34% in two samples taken with a 1-yr interval, respectively, indicating inhomogeneity within the population.The results indicate that the individual differences in kidney Cu concentration have a genetic basis.

摘要

测定了 6 种近交系（BN、F344、LEW、SHR、WAG/Cpb 和 WAG/Rij）和 1 种随机繁殖的 Wistar 大鼠雄性肾脏的铜浓度。在近交系大鼠中，平均值因品系而异，范围从 F344 的 7.10μg/g 到 WAG/Cpb 的 23.48μg/g。遗传决定系数（g(2)）计算为 0.88。在两个 WAG 近交系之间发现了显著差异；WAG/Cpb 的肾脏 Cu 浓度比 WAG/Rij 高 2.5 倍。随机繁殖大鼠的肾脏 Cu 浓度差异很大；在相隔 1 年采集的 2 个样本中，平均值的变异系数分别为 28%和 34%，表明群体内存在异质性。结果表明，肾脏 Cu 浓度的个体差异具有遗传基础。