单次推注替奈普酶与链激酶输注溶栓治疗急性肺栓塞的初步研究
Thrombolysis With Single Bolus Tenecteplase Compared With Streptokinase Infusion in the Treatment of Acute Pulmonary Embolism: A Pilot Study.
作者信息
Patra Soumya, Nagesh C M, Reddy Babu, Srinivas B C, Agrawal Navin, Manjunath C N, Hegde Madhav
机构信息
Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India
Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.
出版信息
Clin Appl Thromb Hemost. 2015 Sep;21(6):550-7. doi: 10.1177/1076029613511524. Epub 2013 Nov 19.
OBJECTIVE
This study was planned to compare the efficacy of bolus regimens of tenecteplase (TNK) and 24 hours infusion of streptokinase (STK) in acute pulmonary embolism (APE) in a resource-poor setting.
INTERVENTIONS
In all, 25 patients received injection of TNK, and 75 patients received infusion of STK over 24 hours.
RESULTS
Pulmonary artery systolic pressure and right ventricular function were improved separately and significantly (P = .01) in both the study groups of patients from baseline at 24 hours or at seventh day and was comparable among the TNK and STK groups of patients. Mean duration of stay in intensive care unit was significantly less (2.2 ± 0.8 vs 3.2 ± 1.3 days; P = .04), and bleeding risk was also found to be nonsignificantly less in the TNK group.
CONCLUSION
These results suggest that a 24-hour infusion regimen of STK is as effective as bolus TNK in the treatment of patients with APE in countries with limited resources.
目的
本研究旨在比较在资源匮乏地区，单次注射替奈普酶（TNK）与24小时输注链激酶（STK）治疗急性肺栓塞（APE）的疗效。
干预措施
总共25例患者接受TNK注射，75例患者接受24小时的STK输注。
结果
两组患者在24小时或第7天时，肺动脉收缩压和右心室功能较基线水平均有显著改善（P = 0.01），且TNK组和STK组患者之间具有可比性。重症监护病房的平均住院时间显著缩短（2.2±0.8天 vs 3.2±1.3天；P = 0.04），并且发现TNK组的出血风险也略低，但无显著差异。
结论
这些结果表明，在资源有限的国家，24小时输注STK方案在治疗APE患者方面与单次注射TNK同样有效。
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