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兔鼻窦黏膜血流测量:荧光素血流测定法与微球及Rb86Cl血流测量法的比较

Blood flow measurements in rabbit sinus mucosa. A comparison between fluorescein flowmetry and blood flow measurements with microspheres and Rb86Cl.

作者信息

Kumlien J, Perbeck L

出版信息

Acta Otolaryngol. 1986 May-Jun;101(5-6):475-83. doi: 10.3109/00016488609108634.

DOI:10.3109/00016488609108634
PMID:2425546
Abstract

The blood flow of the sinus mucosa was studied in 14 rabbits of the New Zealand White strain. The blood flow was determined by fluorescein flowmetry and the values were compared with those obtained from the same sinus mucosa with use of Sn113 radioactively labelled microspheres and with Rb86Cl. One sinus cavity in each animal received nose drops prior to the blood flow measurement. The blood flow index in the sinus mucosa was 0.039 +/- 0.019 density units Xs-1 and was significantly reduced to 0.016 +/- 0.011 density units Xs-1 by administration of nose drops. Blood flow in the sinus mucosa was 1.0 +/- 0.53 ml X min-1 X g-1 as measured with microspheres and 0.52 +/- 0.12 ml X min-1 X g-1 with the Rb86Cl method. Following administration of nose drops the values were reduced to 0.29 +/- 0.13 and 0.22 +/- 0.07 ml X min-1 X g-1 respectively. There was a significant difference in blood flow obtained with the Rb86Cl and microsphere methods in the sinus mucosa without decongestion. This might be explained by possible shunting of blood in the mucosa due to hyperaemia caused by the surgical trauma to the sinus.

摘要

对14只新西兰白兔品系的兔子的鼻窦黏膜血流进行了研究。通过荧光素血流测定法测定血流,并将这些值与使用Sn113放射性标记微球和Rb86Cl从同一鼻窦黏膜获得的值进行比较。在每只动物的一个鼻窦腔内,在血流测量前滴入滴鼻剂。鼻窦黏膜中的血流指数为0.039±0.019密度单位Xs-1,通过滴入滴鼻剂后显著降低至0.016±0.011密度单位Xs-1。用微球测量时,鼻窦黏膜中的血流为1.0±0.53 ml X min-1 X g-1,用Rb86Cl方法测量时为0.52±0.12 ml X min-1 X g-1。滴入滴鼻剂后,这些值分别降至0.29±0.13和0.22±0.07 ml X min-1 X g-1。在未充血的鼻窦黏膜中,用Rb86Cl和微球方法获得的血流存在显著差异。这可能是由于鼻窦手术创伤引起的充血导致黏膜中血液可能出现分流来解释。

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