Lemaitre Caroline, Iwanicki-Caron Isabelle, Vecchi Clément De, Bertiaux-Vandaële Nathalie, Savoye Guillaume
Caroline Lemaitre, Isabelle Iwanicki-Caron, Nathalie Bertiaux-Vandaële, Guillaume Savoye, Department of Gastroenterology, Rouen University Hospital, 76031 Rouen, France.
World J Nephrol. 2013 Aug 6;2(3):90-3. doi: 10.5527/wjn.v2.i3.90.
We report the case of a 44-year-old male patient who presented with acute renal artery occlusion, 3 d after first injection of infliximab for steroid refractory attack of ulcerative colitis. Extensive work-up provided no evidence of predisposing factors for arterial thrombosis. Infliximab was thus suspected in the genesis of thrombosis, based on both intrinsic and extrinsic criteria. At month 3 after thrombosis with ongoing anticoagulation, angio-tomodensitometry showed complete revascularization of the left renal artery with renal atrophy. Renal function remained normal and the patient was still in steroid free remission on mercaptopurin monotherapy at maximal follow-up. Few thromboembolic events have been described with anti- tumor necrosis factor (TNF) agents, but it is the first case reported of renal artery thrombosis after infliximab infusion. In addition, we review thrombosis associated with anti-TNF agents.
我们报告了一例44岁男性患者，该患者在首次注射英夫利昔单抗治疗溃疡性结肠炎激素难治性发作3天后出现急性肾动脉闭塞。全面检查未发现动脉血栓形成的易感因素。基于内在和外在标准，因此怀疑血栓形成与英夫利昔单抗有关。在血栓形成后第3个月，持续抗凝治疗，血管密度测定显示左肾动脉完全再血管化伴肾萎缩。肾功能保持正常，在最长随访期，患者在接受巯嘌呤单药治疗时仍处于无类固醇缓解状态。使用抗肿瘤坏死因子（TNF）药物导致的血栓栓塞事件鲜有报道，但这是首例英夫利昔单抗输注后肾动脉血栓形成的病例报告。此外，我们还综述了与抗TNF药物相关的血栓形成情况。
