Fei Bing, Wu Zheng, Min Kehua, Zhang Jingbo, Ding Chuanlian, Wu Hao
Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Nantong University , Nantong, Jiangsu , PR China.
Acta Otolaryngol. 2014 Mar;134(3):314-7. doi: 10.3109/00016489.2013.850174. Epub 2013 Nov 21.
The T-SPOT test for Mycobacterium tuberculosis infection (T-SPOT.TB) can be used for early diagnosis of laryngeal tuberculosis (TB).
The incidence of TB is increasing on a global scale. Laryngeal TB is the most common extrapulmonary form of TB and its early diagnosis is still difficult. This study investigated the performance of the interferon-γ release assay in the diagnosis of laryngeal TB.
A total of 83 patients with laryngeal neoplasms were confirmed to have laryngeal TB by pathology, acid-fast staining, and/or fluorescence quantitative PCR. In addition, 52 patients with vocal cord polyps were enrolled as the control group. Two groups underwent both T-SPOT.TB and tuberculin skin test (TST).
T-SPOT.TB was positive in 75 cases in the laryngeal TB group and 4 cases in the control group, showing a sensitivity of 90.3% (75/83) and a specificity of 92.3% (48/52). The TST was positive in 42 cases and 20 cases, respectively, in these two groups. Obviously, TST and T-SPOT.TB were significantly different in terms of sensitivity when applied for detection of laryngeal TB (p < 0.05).
结核分枝杆菌感染T细胞斑点试验（T-SPOT.TB）可用于喉结核的早期诊断。
全球范围内结核病发病率呈上升趋势。喉结核是最常见的肺外结核形式，其早期诊断仍存在困难。本研究探讨了γ-干扰素释放试验在喉结核诊断中的性能。
共有83例喉肿瘤患者经病理、抗酸染色和/或荧光定量PCR确诊为喉结核。此外，纳入52例声带息肉患者作为对照组。两组均进行T-SPOT.TB和结核菌素皮肤试验（TST）。
喉结核组75例T-SPOT.TB阳性，对照组4例阳性，灵敏度为90.3%（75/83），特异度为92.3%（48/52）。两组中TST阳性分别为42例和20例。显然，TST和T-SPOT.TB在用于检测喉结核时，灵敏度有显著差异（p<0.05）。
