Kraus Jaroslav, Nártová Eva, Pavlík Emil, Katra Rami, Sterzl Ivan, Astl Jaromír
Department of Otorhinolaryngology, Hospital of Rudolf & Stefanie Benešov.
Acta Otolaryngol. 2014 Jan;134(1):88-92. doi: 10.3109/00016489.2013.840924. Epub 2013 Nov 21.
Our results encourage the notion that the pharynx could be an extragastric reservoir of Helicobacter pylori (HP). The study confirmed the presence of HP in adenotonsillar tissue in children. It could have importance in the pathophysiology of upper respiratory diseases. However, its precise role in these processes remains unclear and requires further studies.
A prospective study was carried out to evaluate the presence of HP in tonsillar and adenoid tissue in children. The study focused on real-time PCR analyzing CagA and VacA genotypes of HP strains.
A total of 37 consecutive pediatric patients with adenotonsillar hypertrophy indicated for surgery were observed in a prospective study. Adenoidectomy and/or tonsillectomy was performed in each patient; 49 specimens were taken, 32 from adenoids and 17 from tonsils. The presence of HP and its genotype were tested in all samples by real-time PCR analysis.
Of 49 samples analyzed, 48 were positive for the presence of HP (98%), so only 1 sample was negative. While the genotype VacAs1bm2 was definitely dominant in adenoid tissue, wider distribution was observed in tonsillar tissue. Cag(+) strains represented one-fifth of all samples (21%).
我们的研究结果支持咽可能是幽门螺杆菌（HP）胃外储存库这一观点。该研究证实了儿童腺样体扁桃体组织中存在HP。它可能在上呼吸道疾病的病理生理学中具有重要意义。然而，其在这些过程中的确切作用仍不清楚，需要进一步研究。
进行一项前瞻性研究，以评估儿童扁桃体和腺样体组织中HP的存在情况。该研究重点是通过实时PCR分析HP菌株的CagA和VacA基因型。
在一项前瞻性研究中，观察了37例因腺样体扁桃体肥大而需手术的连续儿科患者。对每位患者进行腺样体切除术和/或扁桃体切除术；共采集49个标本，其中32个来自腺样体，17个来自扁桃体。通过实时PCR分析检测所有样本中HP的存在及其基因型。
在分析的49个样本中，48个HP检测呈阳性（98%），因此只有1个样本为阴性。虽然VacAs1bm2基因型在腺样体组织中绝对占主导地位，但在扁桃体组织中观察到更广泛的分布。Cag(+)菌株占所有样本的五分之一（21%）。
