沙特人群中的 HLA-B50 多态性。
HLA-B50 polymorphism in the Saudi population.
机构信息
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
出版信息
Int J Immunogenet. 2014 Apr;41(2):95-7. doi: 10.1111/iji.12096. Epub 2013 Nov 21.
The HLA-B50 serologic family is very frequent in people of Arabic origin. In Saudi Arabia, HLA-B50 is the most frequent HLA-B allele. The aim of this study was to investigate the distribution of HLA-B50 alleles in healthy Saudi individuals. A total of 162 healthy Saudi individuals were selected based on low-resolution HLA typing. DNA samples were typed by sequence-based typing method for exons 2, 3 and 4 of the HLA-B locus (Genome Diagnostics B.V.). The HLA-B50 alleles were analysed using SBT engine software. HLA-B50:01:01 was found in 161 of 162 individuals (99.4%), while HLA-B50:09 was found in one individual (0.6%). HLA-B50:01:01 is the most common HLA-B50 allele in Saudi Arabia.
HLA-B50 血清型家族在阿拉伯裔人群中非常常见。在沙特阿拉伯，HLA-B50 是最常见的 HLA-B 等位基因。本研究旨在调查 HLA-B50 等位基因在沙特健康个体中的分布。根据低分辨率 HLA 分型，共选择了 162 名健康的沙特个体。使用基于序列的分型方法对 HLA-B 基因座的外显子 2、3 和 4 进行 DNA 样本分型（Genome Diagnostics B.V.）。使用 SBT 引擎软件分析 HLA-B50 等位基因。在 162 名个体中均发现了 HLA-B50:01:01（99.4%），而在 1 名个体中发现了 HLA-B50:09（0.6%）。HLA-B50:01:01 是沙特阿拉伯最常见的 HLA-B50 等位基因。
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