在沙特个体中鉴定出两个新的等位基因HLA-DRB1*11:150和HLA-DRB1*14:145。
Two novel alleles HLA-DRB1*11:150 and HLA-DRB1*14:145 identified in Saudi individuals.
作者信息
Fakhoury H A, Cereb N, Jawdat D, Al Jumah M, Alaskar A S, Hajeer A H
机构信息
Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi Arabia.
出版信息
Int J Immunogenet. 2014 Aug;41(4):340-1. doi: 10.1111/iji.12133. Epub 2014 Jun 12.
Two new HLA- DRB1 alleles were identified by sequence-based typing method (SBT) in 1100 participants in the Saudi Stem Cell Donor Registry. HLA-DRB111:150 differs from HLA-DRB111:01:01G by a single C to A substitution at nucleotide position 5580 in exon 2, resulting in an amino acid change from alanine to glutamic acid at position 74. HLA-DRB114:145 differs from HLA-DRB114:04 by a C to G substitution at nucleotide position 5511 in exon 2, resulting in an amino acid change from threonine to arginine at position 51.
通过基于序列的分型方法（SBT），在沙特干细胞供体登记处的1100名参与者中鉴定出两个新的HLA-DRB1等位基因。HLA-DRB111:150与HLA-DRB111:01:01G的区别在于，外显子2中核苷酸位置5580处发生了单个C到A的替换，导致第74位氨基酸从丙氨酸变为谷氨酸。HLA-DRB114:145与HLA-DRB114:04的区别在于，外显子2中核苷酸位置5511处发生了C到G的替换，导致第51位氨基酸从苏氨酸变为精氨酸。
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