Aziz H, Choi K, Sohn C, Yaes R, Rotman M
Am J Clin Oncol. 1986 Jun;9(3):264-8. doi: 10.1097/00000421-198606000-00017.
We report a retrospective study of 15 patients with prostate carcinoma and diffuse bone metastases treated with sodium 32P for palliation of pain at Downstate Medical Center and Kings County Hospital from 1973 to 1978. The response rates, duration of response, and toxicities are compared with those of other series of patients treated with 32P and with sequential hemibody irradiation. The response rates and duration of response are similar with both modalities ranging from 58 to 95% with a duration of 3.3 to 6 months with 32P and from 75 to 86% with a median duration of 5.5 months with hemibody irradiation. There are significant differences in the patterns of response and in the toxicities of the two treatment methods. Both methods cause significant bone marrow depression. Acute radiation syndrome, radiation pneumonitis, and alopecia are seen with sequential hemibody irradiation and not with 32P, but their incidence can be reduced by careful treatment planning. Hemibody irradiation can provide pain relief within 24 to 48 h, while 32P may produce an initial exacerbation of pain. Lower hemibody irradiation alone is less toxic than either upper hemibody irradiation or 32P treatment.
我们报告了一项回顾性研究，该研究对1973年至1978年期间在唐斯泰特医学中心和国王郡医院接受32P钠治疗以缓解疼痛的15例前列腺癌伴弥漫性骨转移患者进行了研究。将这些患者的缓解率、缓解持续时间和毒性与其他接受32P治疗以及序贯半身照射的患者系列进行了比较。两种治疗方式的缓解率和缓解持续时间相似，32P治疗的缓解率为58%至95%，缓解持续时间为3.3至6个月，半身照射的缓解率为75%至86%，中位缓解持续时间为5.5个月。两种治疗方法在缓解模式和毒性方面存在显著差异。两种方法都会导致明显的骨髓抑制。序贯半身照射会出现急性放射综合征、放射性肺炎和脱发，而32P治疗则不会，但通过精心的治疗计划可以降低其发生率。半身照射可在24至48小时内缓解疼痛，而32P治疗可能会使疼痛最初加剧。单独进行下半身照射的毒性低于上半身照射或32P治疗。
