*Sheffield Institute for Translational Neuroscience (SITraN), 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, U.K.
Biochem Soc Trans. 2013 Dec;41(6):1583-7. doi: 10.1042/BST20130140.
The ECs (endocannabinoids) AEA (anandamide) and 2-AG (2-arachidonoylglycerol) and their lipid congeners OEA (N-oleoylethanolamide) and PEA (N-palmitoylethanolamide) are multifunctional lipophilic signalling molecules. The ECs, OEA and PEA have multiple physiological roles including involvement in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. They have also been implicated in the pathology of, or perhaps protective responses to, neurodegenerative diseases. This is particularly the case with Alzheimer's disease, the most common age-related dementia associated with impairments in learning and memory accompanied by neuroinflammation, oxidative stress and neurodegeneration. The present mini-review examines the evidence supporting the roles that ECs appear to play in Alzheimer's disease and the potential for beneficial therapeutic manipulation of the EC signalling system.
ECs（内源性大麻素），如 AEA（花生四烯酰乙醇胺）和 2-AG（2-花生四烯酰甘油），以及它们的脂质同系物 OEA（N-油酰乙醇胺）和 PEA（N-棕榈酰乙醇胺）是多功能亲脂信号分子。ECs、OEA 和 PEA 具有多种生理作用，包括参与学习和记忆、神经炎症、氧化应激、神经保护和神经发生。它们也与神经退行性疾病的病理学或可能的保护反应有关。在阿尔茨海默病中尤其如此，阿尔茨海默病是最常见的与学习和记忆障碍相关的与年龄相关的痴呆症，伴有神经炎症、氧化应激和神经退行性变。本综述探讨了支持 ECs 在阿尔茨海默病中发挥作用的证据，以及对 EC 信号系统进行有益的治疗干预的潜力。
