*Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A.
Biochem Soc Trans. 2013 Dec;41(6):1750-4. doi: 10.1042/BST20130208.
Cytokinesis, the terminal event in the canonical cell cycle, physically separates daughter cells following mitosis. For cleavage to occur in many eukaryotes, a cytokinetic ring must assemble and constrict between divided genomes. Although dozens of different molecules localize to and participate within the cytokinetic ring, the core machinery comprises linear actin filaments. Accordingly, formins, which nucleate and elongate F-actin (filamentous actin) for the cytokinetic ring, are required for cytokinesis in diverse species. In the present article, we discuss specific modes of formin-based actin regulation during cell division and highlight emerging mechanisms and questions on this topic.
有丝分裂后，胞质分裂是经典细胞周期的最后一个事件，将子细胞物理性地分隔开。对于许多真核生物来说，有丝分裂后必须组装和收缩细胞分裂环才能发生胞质分裂。虽然数十种不同的分子定位于细胞分裂环并参与其中，但核心机械装置包括线性肌动蛋白丝。因此，对于细胞分裂来说，形成素（formin）是必需的，它可以为细胞分裂环起始和延伸 F-actin（丝状肌动蛋白）。在本文中，我们讨论了细胞分裂过程中基于形成素的肌动蛋白调节的具体模式，并强调了该主题的新兴机制和问题。
