关于阿仑膦酸盐相关颌骨坏死的重要方面：文献综述
Important aspects concerning alendronate-related osteonecrosis of the jaws: a literature review.
作者信息
Iglesias Julia E, Salum Fernanda G, Figueiredo Maria A, Cherubini Karen
机构信息
Dental College, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Postgraduate Program of Dental College, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
出版信息
Gerodontology. 2015 Sep;32(3):169-78. doi: 10.1111/ger.12093. Epub 2013 Nov 21.
OBJECTIVE
To conduct a literature review on sodium alendronate, focusing on osteonecrosis of the jaws, a serious potential side effect.
BACKGROUND
Sodium alendronate is a bisphosphonate that is widely used for the treatment of osteopenia, osteoporosis and Paget's disease. Like other bisphosphonates, it inhibits bone resorption by inactivating osteoclasts. Alendronate has evident benefits in the treatment of these diseases, but it is associated with jaw osteonecrosis, although less frequently compared with intravenous bisphosphonates. Therefore, some preventive measures should be taken to avoid this side effect.
MATERIAL AND METHODS
We reviewed the literature regarding the pharmacological aspects, mechanism of action, indications of use and side effects of sodium alendronate, as well as the management of patients under this therapy.
CONCLUSION
The benefits of sodium alendronate are scientifically proven, but a serious adverse effect is osteonecrosis. Therefore, it is crucial to prepare the oral cavity before bisphosphonate therapy, providing a careful dental evaluation and all needed dental treatment.
目的
对阿仑膦酸钠进行文献综述，重点关注颌骨坏死这一严重的潜在副作用。
背景
阿仑膦酸钠是一种双膦酸盐，广泛用于治疗骨质减少、骨质疏松症和佩吉特病。与其他双膦酸盐一样，它通过使破骨细胞失活来抑制骨吸收。阿仑膦酸钠在治疗这些疾病方面有明显益处，但它与颌骨坏死有关，尽管与静脉注射双膦酸盐相比发生率较低。因此，应采取一些预防措施以避免这种副作用。
材料与方法
我们查阅了有关阿仑膦酸钠的药理学方面、作用机制、使用指征和副作用以及接受该治疗的患者管理的文献。
结论
阿仑膦酸钠的益处已得到科学证明，但严重的不良反应是颌骨坏死。因此，在双膦酸盐治疗前对口腔进行准备，进行仔细的牙科评估和所有必要的牙科治疗至关重要。
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