Van Neste D J, Staquet M J
Am J Dermatopathol. 1986 Jun;8(3):267-73. doi: 10.1097/00000372-198606000-00018.
We compared some morphological and biochemical aspects of the epidermal changes occurring in hyperkeratotic scabies in humans and domestic pigs. Clinically and histologically, pig skin alterations look very similar to those observed in humans, i.e., brittle hyperkeratosis with parakeratotic crusting and thickening of the epidermis. Parakeratosis seems to correspond to previous passage of scabies mites through the incompletely differentiated layers of the epidermis. Indeed, by serial sectioning we observed beneath the stratum corneum cellular lysis some distance ahead of the mouth parts of the parasites. Epidermal cells surrounding this initial epidermolytic focus finally underwent disturbed terminal differentiation and appeared as parakeratotic cells. In pigs we observed intraepithelial microabscesses, but we rarely observed these in our human subjects.
我们比较了人类和家猪角化过度型疥疮中发生的表皮变化的一些形态学和生物化学方面。在临床和组织学上，猪的皮肤改变与人类观察到的非常相似，即伴有不全角化结痂的脆性角化过度和表皮增厚。不全角化似乎与先前疥螨穿过表皮未完全分化层有关。事实上，通过连续切片，我们在角质层下方寄生虫口器前方一段距离处观察到细胞溶解。围绕这个初始表皮溶解灶的表皮细胞最终经历了紊乱的终末分化，并呈现为不全角化细胞。在猪身上我们观察到上皮内微脓肿，但在人类受试者中很少观察到。
