SPARC和Vav3在脑膜瘤中的表达：与预后相关的因素

SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis.

作者信息

Jiang Jie, Song Yuejia, Liu Nan, Lin Chengjun, Zhao Shiguang, Sun Yu, Zhang Zhen, Fang Xiang, Qi Jiping

出版信息

Can J Neurol Sci. 2013 Nov;40(6):814-8. doi: 10.1017/s0317167100015948.

DOI:10.1017/s0317167100015948

PMID:24257222

Abstract

BACKGROUND

Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma.

METHODS

We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades.

RESULTS

The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly increased with meningioma grade (p<0.01), and was higher in brain-invasive meningiomas compared to non-invasive meningiomas (WHO grade I) (p<0.05). Furthermore, the expression of Vav3, p-Akt, and Ki-67 was higher in recurrent meningiomas compared to non-recurrent meningiomas (WHO grade I) (p<0.05).

CONCLUSION

The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in meningiomas appears to correlate with meningioma invasiveness, aggressiveness, and recurrence.

UNLABELLED

Expression de SPARC et de Vav3 dans le méningiome : facteurs reliés au pronostic.

摘要

背景

脑膜瘤约占原发性颅内肿瘤的24 - 30%。组织病理学分级和切除程度是两个主要的预后因素。本研究的目的是确定与脑膜瘤预后相关的因素。

方法

我们采用免疫组织化学方法分析了287例各级脑膜瘤中Vav3、SPARC、p-Akt、细胞周期蛋白D1和Ki-67的表达水平。

结果

Vav3、SPARC、p-Akt、细胞周期蛋白D1和Ki-67的表达随脑膜瘤分级显著增加（p<0.01），与非侵袭性脑膜瘤（WHO I级）相比，侵袭性脑膜瘤中的表达更高（p<0.05）。此外，与非复发性脑膜瘤（WHO I级）相比，复发性脑膜瘤中Vav3、p-Akt和Ki-67的表达更高（p<0.05）。