Department of Hospital Pathology, The Catholic University of Korea, College of Medicine, Seoul, Korea.
APMIS. 2014 Jan;122(1):16-24. doi: 10.1111/apm.12079. Epub 2013 Jun 12.
Meningiomas are slow-growing neoplasms that recur locally. Their morphologic grading does not always correlate with patient outcome. We evaluated the status of several immunohistochemical markers with histopathologic parameters in various grades of meningioma.Eighty-eight meningioma specimens were examined immunohistochemically to determine the status of Ki-67, cyclin D1, epidermal growth factor receptor (EGFR), cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), and bcl-2. Several clinical and pathological parameters were investigated.Forty-nine Grade I, 33 Grade II, and 6 Grade III meningiomas were observed. VEGF and Ki-67 expression was correlated with higher tumor grade. The association between grade and other immunohistochemical markers expression was not significant. A correlation was observed between COX-2 expression and invasiveness to the brain or adjacent soft tissue. Tumor recurrence was correlated with brain or adjacent soft tissue invasion. We also observed a relationship between VEGF level and COX-2 expression, and they were both correlated with necrosis.Immunohistochemical evaluation of VEGF, COX-2, and Ki-67 expression can provide information regarding the behavior of meningiomas, particularly for cases in which histological grading is not straightforward.
脑膜瘤是生长缓慢的肿瘤，会局部复发。它们的形态分级并不总是与患者的预后相关。我们评估了几种免疫组织化学标志物在不同分级脑膜瘤中的组织病理学参数的状态。
对 88 例脑膜瘤标本进行了免疫组织化学检查，以确定 Ki-67、细胞周期蛋白 D1、表皮生长因子受体 (EGFR)、环氧化酶-2 (COX-2)、血管内皮生长因子 (VEGF) 和 bcl-2 的状态。研究了几个临床和病理参数。
观察到 49 级 I 型、33 级 II 型和 6 级 III 型脑膜瘤。VEGF 和 Ki-67 的表达与肿瘤分级较高有关。其他免疫组织化学标志物表达与分级之间的相关性不显著。COX-2 表达与脑或邻近软组织侵袭有关。肿瘤复发与脑或邻近软组织侵袭有关。我们还观察到 VEGF 水平与 COX-2 表达之间存在关系，它们都与坏死有关。
VEGF、COX-2 和 Ki-67 表达的免疫组织化学评估可为脑膜瘤的行为提供信息，特别是在组织学分级不明确的情况下。
