Massey University, School of Sport and Exercise.
J Atheroscler Thromb. 2014;21(1):11-6. doi: 10.5551/jat.20008. Epub 2013 Nov 19.
Pulse wave analysis(PWA) is widely used to investigate systemic arterial stiffness. The augmentation index(AIx), the primary outcome derived from PWA, is influenced by the mean arterial pressure(MAP), age, gender and heart rate(HR). Gender- and age-specific reference values have been devised, and it is recommended that the MAP be used as a statistical covariate. The AIx is also commonly statistically adjusted to a HR of 75 b·min(-1); however, this approach may be physiologically and statistically inappropriate. First, there appears to be an important physiological chronic interaction between HR and arterial stiffness. Second, the method used to correct to HR assumes that the relationship with AIx is uniform across populations. A more appropriate practice may be to include HR as an independent predictor or covariate; this approach is particularly recommended for longitudinal studies, in which changes in HR may help to explain changes in arterial stiffness.
脉搏波分析（PWA）广泛用于研究系统性动脉僵硬。PWA 得出的主要结果是增强指数（AIx），它受平均动脉压（MAP）、年龄、性别和心率（HR）的影响。已经制定了性别和年龄特异性参考值，并建议将 MAP 用作统计协变量。AIx 也通常被统计调整为 75 次 b·min(-1)；然而，这种方法在生理和统计学上可能是不合适的。首先，心率和动脉僵硬之间似乎存在重要的生理慢性相互作用。其次，用于校正 HR 的方法假设与 AIx 的关系在人群中是均匀的。一种更合适的做法可能是将 HR 作为独立预测因子或协变量包含在内；这种方法特别推荐用于纵向研究，其中 HR 的变化可能有助于解释动脉僵硬的变化。
