Université de Lyon-Institut des Sciences Analytiques, UMR 5280 CNRS-Equipe TRACES, Université Lyon1, ENS-Lyon - 5 rue de la Doua, 69100, Villeurbanne, France.
Anal Bioanal Chem. 2014 Feb;406(4):1259-66. doi: 10.1007/s00216-013-7450-8. Epub 2013 Nov 21.
Emerging contaminants are suspected to cause adverse effects in humans and wildlife. Aquatic ecosystems are continuously contaminated by agricultural and industrial sources. To establish a causality relationship between the occurrence of contaminants in the environment and disease, experiments including all environmental matrices must be performed. Consequently, the current analytical tools must be improved. A new multi-residue method for analysing 15 emerging pollutants in sediments based on the Quick, Easy, Cheap, Effective, Rugged and Safe approach is reported. The development of such a multirisque, inter-family method for sediment including pharmaceuticals, pesticides, personal care products and plasticizers is reported for the first time. The procedure involves salting-out liquid-liquid extraction using acetonitrile and clean-up with dispersive solid phase extraction, followed by liquid chromatography coupled with tandem mass spectrometry. The validated analytical procedure exhibited recoveries between 40 and 98% for every target compound. This methodology facilitated the determination of pollutant contents at nanogram-per-gram concentrations.
新兴污染物被怀疑会对人类和野生动物造成不良影响。水生生态系统不断受到农业和工业污染源的污染。为了在环境中污染物的出现与疾病之间建立因果关系，必须进行包括所有环境基质的实验。因此，当前的分析工具必须得到改进。本文报道了一种基于快速、简单、廉价、有效、坚固和安全方法的用于分析沉积物中 15 种新兴污染物的多残留方法。这是首次报道用于沉积物的多风险、跨家族的药物、农药、个人护理产品和增塑剂的方法。该程序涉及使用乙腈进行盐析液-液萃取和分散固相萃取净化，然后进行液相色谱-串联质谱分析。经验证的分析程序对每个目标化合物的回收率在 40%至 98%之间。该方法能够测定纳克/克浓度的污染物含量。
