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本文引用的文献

1
Effect of metformin on prostate cancer outcomes after radical prostatectomy.二甲双胍对前列腺癌根治术后预后的影响。
Urol Oncol. 2014 Jan;32(1):43.e1-7. doi: 10.1016/j.urolonc.2013.05.005. Epub 2013 Jun 28.
2
Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma.二甲双胍使用与喉鳞状细胞癌患者生存率提高之间的关联。
Head Neck. 2014 Jul;36(7):1039-43. doi: 10.1002/hed.23409. Epub 2014 Jan 29.
3
Diabetes, metformin use, and colorectal cancer survival in postmenopausal women.糖尿病、二甲双胍的使用与绝经后女性结直肠癌的生存
Cancer Epidemiol. 2013 Oct;37(5):742-9. doi: 10.1016/j.canep.2013.04.015. Epub 2013 Jun 15.
4
A cohort study of metformin exposure and survival in patients with stage I-III colorectal cancer.一项关于二甲双胍暴露与 I-III 期结直肠癌患者生存关系的队列研究。
Cancer Epidemiol Biomarkers Prev. 2013 Aug;22(8):1364-73. doi: 10.1158/1055-9965.EPI-13-0347. Epub 2013 Jun 10.
5
Association between metformin therapy and mortality after breast cancer: a population-based study.二甲双胍治疗与乳腺癌后死亡率的关联：一项基于人群的研究。
Diabetes Care. 2013 Oct;36(10):3018-26. doi: 10.2337/dc12-2535. Epub 2013 Apr 30.
6
Clinical pathological characteristics and prognostic analysis of 1,013 breast cancer patients with diabetes.1,013 例糖尿病乳腺癌患者的临床病理特征及预后分析。
Breast Cancer Res Treat. 2013 Feb;137(3):807-16. doi: 10.1007/s10549-012-2404-y. Epub 2013 Jan 6.
7
Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality.二甲双胍与前列腺癌：降低去势抵抗性疾病的发展和前列腺癌死亡率。
Eur Urol. 2013 Apr;63(4):709-16. doi: 10.1016/j.eururo.2012.12.004. Epub 2012 Dec 14.
8
[The effect of metformin on responses to chemotherapy and survival in stage IV colorectal cancer with diabetes].二甲双胍对IV期结直肠癌合并糖尿病患者化疗反应及生存的影响
Korean J Gastroenterol. 2012 Dec;60(6):355-61. doi: 10.4166/kjg.2012.60.6.355.
9
Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel.二甲双胍下调依赖 p38 丝裂原活化蛋白激酶的切除修复交叉互补基因 1 降低 DNA 修复能力并使人类肺癌细胞对紫杉醇敏感。
Biochem Pharmacol. 2013 Feb 15;85(4):583-94. doi: 10.1016/j.bcp.2012.12.001. Epub 2012 Dec 7.
10
Metformin intake is associated with better survival in ovarian cancer: a case-control study.二甲双胍的摄入与卵巢癌患者的生存改善相关：一项病例对照研究。
Cancer. 2013 Feb 1;119(3):555-62. doi: 10.1002/cncr.27706. Epub 2012 Dec 3.

二甲双胍与同时患有 2 型糖尿病的癌症患者的生存获益相关：系统评价和荟萃分析。

Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis.

机构信息

Department of Internal Medicine.

出版信息

Oncologist. 2013;18(12):1248-55. doi: 10.1634/theoncologist.2013-0111. Epub 2013 Nov 20.

DOI:10.1634/theoncologist.2013-0111
PMID:24258613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3868417/
Abstract

UNLABELLED

Patients with type 2 diabetes have increased cancer risk and cancer-related mortality, which can be reduced by metformin treatment. However, it is unclear whether metformin can also modulate clinical outcomes in patients with cancer and concurrent type 2 diabetes.

PATIENTS AND METHODS

A meta-analysis of 20 publications that included 13,008 subjects was performed to investigate the association between metformin and overall survival (OS) as well as cancer-specific survival (CSS) in patients with cancer and concurrent type 2 diabetes.

RESULTS

We found that there was a relative survival benefit associated with metformin treatment compared with treatment with other glucose-lowering medications in both OS and CSS (hazard ratio [HR] = 0.66; 95% confidence interval [CI]: 0.55-0.79 and HR = 0.62; 95% CI: 0.46-0.84, respectively). These associations were also observed in subgroups by cancer type and country.

CONCLUSION

These results suggest that metformin is the drug of choice in the treatment of patients with cancer and concurrent type 2 diabetes.

摘要

目的

研究癌症合并 2 型糖尿病患者中二甲双胍与总生存（OS）和癌症特异性生存（CSS）的关系。

患者和方法

对纳入 13008 例患者的 20 项研究进行荟萃分析，以探讨癌症合并 2 型糖尿病患者中二甲双胍与 OS 和 CSS 的关系。

结果

我们发现，与其他降糖药物相比，二甲双胍治疗与 OS 和 CSS 相关的生存获益相关（风险比 [HR] = 0.66；95%置信区间 [CI]：0.55-0.79 和 HR = 0.62；95% CI：0.46-0.84）。这些关联在按癌症类型和国家划分的亚组中也观察到。

结论

这些结果表明，二甲双胍是治疗癌症合并 2 型糖尿病患者的首选药物。