Saldiva P H, Massad E, Caldeira M P, Calheiros D F, Saldiva C D, Nicolelis M A, Böhm G M
Braz J Med Biol Res. 1985;18(4):573-7.
This paper describes the effects of repeated exposure to gasoline and ethanol exhaust fumes on the pulmonary mechanics of rats assessed by whole-body plethysmography. Two groups of 12 male Wistar albino rats each were tested before and after exposure to diluted gasoline or ethanol exhaust gases for 5 weeks, 8 h per day and 5 days per week. An additional group of 12 rats were exposed to clean air under the same experimental conditions. The variations of the functional parameters observed in the three groups before and after exposure were compared. Peak Expiratory Flow and Forced Expiratory Mean Flows in the ranges 0-25%, 25-50% and 50-75% of Forced Vital Capacity were significantly reduced in animals exposed to gasoline exhaust fumes, whereas the group exposed to ethanol exhaust fumes did not differ from the control group. This respiratory impairment is probably due to the presence of SO2 and the quality of the hydrocarbons in gasoline exhaust gases.
本文描述了通过全身体积描记法评估的反复暴露于汽油和乙醇废气对大鼠肺力学的影响。两组，每组12只雄性Wistar白化大鼠，在每天8小时、每周5天暴露于稀释的汽油或乙醇废气5周之前和之后进行测试。另外一组12只大鼠在相同实验条件下暴露于清洁空气中。比较了三组在暴露前后观察到的功能参数变化。暴露于汽油废气的动物，其用力肺活量0-25%、25-50%和50-75%范围内的呼气峰值流速和用力呼气平均流速显著降低，而暴露于乙醇废气的组与对照组无差异。这种呼吸功能损害可能是由于汽油废气中存在二氧化硫和碳氢化合物的质量所致。
