多关节炎大鼠中乙酰胆碱酯酶分子形式的慢速和快速轴突运输

Slow and fast axonal transport of acetylcholinesterase molecular forms in polyarthritic rats.

作者信息

Tavitian B, Hassig R, Di Giamberardino L, Besson J M

出版信息

Brain Res. 1986 Jun 11;375(2):391-4. doi: 10.1016/0006-8993(86)90765-1.

Abstract

Acetylcholinesterase (AChE) activity and its distribution among different molecular forms were studied in the sciatic nerve of normal and polyarthritic rats. Axonal transport of each form was investigated on the basis of its accumulation on both sides of a transection. Although an increase in total AChE activity could be detected in the sciatic nerves of polyarthritic animals, both anterograde and retrograde axonal transport of all the molecular forms investigated were similar in normal and polyarthritic rats. This suggests that neither slow nor fast axonal transport is impaired in polyarthritic rats. Hence, the neurophysiological modifications observed at the spinal, thalamic and cortical levels of the CNS are presumably not a consequence of peripheral axonal disability.

摘要

研究了正常大鼠和多关节炎大鼠坐骨神经中乙酰胆碱酯酶（AChE）的活性及其在不同分子形式之间的分布。根据每种形式在横断两侧的积累情况研究其轴突运输。虽然在多关节炎动物的坐骨神经中可检测到总AChE活性增加，但在正常大鼠和多关节炎大鼠中，所研究的所有分子形式的顺行和逆行轴突运输均相似。这表明多关节炎大鼠的慢速和快速轴突运输均未受损。因此，在中枢神经系统的脊髓、丘脑和皮质水平观察到的神经生理学改变可能不是外周轴突功能障碍的结果。