Department of Biology, University of California, San Diego, 92093, La Jolla, California.
Biol Trace Elem Res. 1985 Mar;7(2):75-81. doi: 10.1007/BF02916565.
The metabolism of orally administered radiomanganese was studied in mice. Assimilation of absorbed manganese (Mn) was determined using whole body counting techniques. When(54)MnCl2 was administered, 2.7% of the dose was retained after 10 d compared with 1.2% from the(54)Mn-nitrilotriacetate (NTA) complex. However, this difference was accounted for by the rapid and persistent adsorption of the Mn onto the teeth of the lower jaw when fed as the ionic salt at pH 2.0 compared with the NTA-chelate fed at pH 9.0. Once corrected for the amount adsorbed onto the teeth, the biodistribution and relative specific activity of the assimilated radiomanganese into a variety of tissues were similar for both forms of the metal.
经口给予放射性锰的代谢在小鼠中进行了研究。使用全身计数技术确定吸收锰（Mn）的同化。当给予(54)MnCl2 时，与(54)Mn-亚氨基二乙酸（NTA）络合物的 1.2%相比，10 天后保留了 2.7%的剂量。然而，这种差异是由于在 pH 2.0 下作为离子盐给予时，Mn 迅速且持续地吸附在下颌牙齿上，而在 pH 9.0 下给予 NTA 螯合物时，Mn 迅速且持续地吸附在下颌牙齿上。一旦校正了吸附到牙齿上的量，两种形式的金属的同化放射性锰在各种组织中的分布和相对比活度就相似。
