共价偶联免疫刺激剂异二聚体。
Covalently coupled immunostimulant heterodimers.
机构信息
Department of Chemistry, University of California, Irvine, 3038A Frederick Reines Hall, Irvine, CA 92697-2025 (USA).
出版信息
Angew Chem Int Ed Engl. 2014 Jan 3;53(1):189-92. doi: 10.1002/anie.201306551. Epub 2013 Nov 20.
Abstract
We report increased stimulation of dendritic cells via heterodimers of immunostimulants formed at a discrete molecular distance. Many vaccines present spatially organized agonists to immune cell receptors. These receptors cluster suggesting that signaling is increased by spatial organization and receptor proximity, but this has not been directly tested for multiple, unique receptors. In this study we probe the spatial aspect of immune cell activation using heterodimers of two covalently attached immunostimulants.
摘要
我们报告说，通过在离散分子距离处形成的免疫刺激剂异二聚体，树突状细胞的刺激增加。许多疫苗将空间组织的激动剂呈现给免疫细胞受体。这些受体簇集表明信号转导通过空间组织和受体接近度增加，但尚未针对多个独特受体进行直接测试。在这项研究中，我们使用两种共价附着的免疫刺激剂的异二聚体来探测免疫细胞激活的空间方面。
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