Kirikkale University School of Medicine, Department of Immunology and Allergic Diseases, Kirikkale, Turkey.
J Investig Allergol Clin Immunol. 2013;23(5):315-22.
Allergic rhinitis (AR) is a common chronic condition with significant consequences if left untreated (e.g., poor health outcomes, disease progression, and increased health care costs). However, about half of all patients do not fill their prescription.The factors associated with adherence are complex, and many remain poorly defined and understood.
This pilot study had 2 objectives. First, to determine whether the medication adherence report scale (MARS) can be applied to identify adherence/nonadherence in patients with AR using patients with chronic obstructive pulmonary disease (COPD) as controls. Second, to identify AR profiles that indicate a particularly high risk of nonadherence.
AR patients completed the Eysenck Personality Questionnaire-Revised Abbreviated-Form (EPQR-A), the Short Form 36 Health Survey (SF-36), the Mini Rhinitis Quality of Life Questionnaire (Mini-RQLQ), and the MARS. Symptom severity was assessed before and after treatment.
The study population comprised 85 AR patients and 50 COPD patients. Females had worse adherence (significant only in total and unintentional scores) and higher extraversion scores. None of the personality traits predicted adherence. Neuroticism was negatively correlated with the SF-36 score (P < .001). A low to moderate correlation was observed between posttreatment improvement in specific/ generic health-related quality of life and MARS scores in AR patients (P = .002, r = 0.332; and P = .022, r = -0.251; respectively). Higher educational level was found to significantly increase adherence (P = .01, r = 0.223).
Our study did not reveal a personality effect. However, it did suggest that use of a brief, self-completed medication adherence questionnaire in daily practice can enable health professionals to identify suboptimal adherence in patients who would benefit from close follow-up.
过敏性鼻炎（AR）是一种常见的慢性疾病，如果不治疗，会产生严重后果（例如健康状况不佳、疾病进展和增加医疗保健费用）。然而，大约有一半的患者没有服药。与依从性相关的因素很复杂，其中许多因素仍定义和理解得不够完善。
本初步研究有两个目的。首先，确定用药依从性报告量表（MARS）是否可用于识别 AR 患者的依从性/不依从性，以慢性阻塞性肺疾病（COPD）患者作为对照。其次，确定提示高不依从风险的 AR 特征。
AR 患者完成艾森克人格问卷修订短式量表（EPQR-A）、36 项简明健康状况量表（SF-36）、迷你鼻炎生活质量问卷（Mini-RQLQ）和 MARS。在治疗前后评估症状严重程度。
研究人群包括 85 名 AR 患者和 50 名 COPD 患者。女性的依从性较差（仅在总得分和非故意得分上具有显著差异），且外向得分较高。没有一种人格特质可以预测依从性。神经质与 SF-36 评分呈负相关（P＜0.001）。AR 患者治疗后特定/一般健康相关生活质量的改善与 MARS 评分之间存在低到中度相关性（P=0.002，r=0.332；P=0.022，r=-0.251）。发现较高的教育水平显著提高了依从性（P=0.01，r=0.223）。
本研究未发现人格效应。然而，它确实表明，在日常实践中使用简短的、自我完成的用药依从性问卷可以使卫生专业人员识别出需要密切随访的依从性不佳的患者。
