Boonme Prapaporn, Maneenuan Duangkhae, Channarong Sunee
Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkla, Thailand.
Int J Pharm Compd. 2013 Jul-Aug;17(4):347-50.
The aim of this study was to prepare coconut oil lotions using a hydrophile-lipophile balance system to calculate the proportion of each nonionic surfactant used. The effects of emulsifier pairs in the formulations on physical properties (i.e., appearance, emulsion type, pH, flow type, viscosity) were investigated. The physical stability of the lotions was determined at ambient temperature (approximatley 30 degrees C) after the lotions were kept for 30 as well as 60 days and in accelerated conditions (6 freeze-thaw cycles). It was found that the formulations most tolerant to such harsh conditions were F1 and F2, o/w lotions containing 40% w/w coconut oil, 50% w/w water and 10% w/w of the mixed emulsifier of a low hydrophile-lipophile balance surfactant (sorbitan monostearate) and a high hydrophile-lipophile balance surfactant (either polyoxyethylene [20] sorbitan monooleate or polyethylene [20] sorbitan monolaurate).
本研究的目的是使用亲水亲油平衡系统制备椰子油乳液,以计算每种非离子表面活性剂的使用比例。研究了配方中乳化剂对的组合对物理性质(即外观、乳液类型、pH值、流动类型、粘度)的影响。在乳液保存30天和60天后以及在加速条件下(6次冻融循环),于环境温度(约30摄氏度)下测定乳液的物理稳定性。结果发现,对如此苛刻条件耐受性最强的配方是F1和F2,即o/w型乳液,含有40%(w/w)的椰子油、50%(w/w)的水和10%(w/w)的低亲水亲油平衡表面活性剂(山梨醇单硬脂酸酯)与高亲水亲油平衡表面活性剂(聚氧乙烯[20]山梨醇单油酸酯或聚氧乙烯[20]山梨醇单月桂酸酯)的混合乳化剂。