Songkro Sarunyoo, Pengmak Somuredee, Seajung Pornyamol, Maneenuan Duangkhae, Kaewnopparat Nattha
Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Int J Pharm Compd. 2018 Sep-Oct;22(5):424-432.
Vetiveria zizanioides (vetiver) contains viscous volatile oil, which has the ability to repel mosquitoes similar to citronella oil, a well-known mosquito repellent in tropical countries, like Thailand. The objectives of the current study were to formulate the stable oil-in-water vetiver oil lotions using Simulgel FL as a liquid emulsifier, to investigate the physicochemical properties of the prepared lotions and to evaluate the in vitro release characteristics of the stable vetiver oil lotions. In this work, the concentrations of Simulgel FL ranged from 1% to 3% weight in weight, whereas the concentrations of vetiver oil were varied: 2.5%, 5%, and 10% weight in weight. The suitable concentration of Simulgel FL was found to be 3% weight in weight. For comparison purposes, oil-in-water citronella oil lotions (10% weightin- weight citronella oil) were also prepared with similar ingredients. A mixture of vetiver oil and citronella oil (1:1 by weight) was also used as an active ingredient. By using Simulgel FL, the lotions could be prepared using a cold process (without heat). The physicochemical properties (appearance, pH, viscosity) of the stable lotions were satisfactory. All prepared lotions possessed weak acidic pH values with pseudoplastic flows. Using modified Franz diffusion cell and synthetic membrane, the release rates of vetiver oil were relatively lower than those of citronella oil.
香根草含有粘性挥发油，其具有类似于香茅油的驱蚊能力，香茅油是热带国家（如泰国）一种著名的驱蚊剂。本研究的目的是使用Simulgel FL作为液体乳化剂来制备稳定的水包油型香根草油乳液，研究制备乳液的物理化学性质，并评估稳定的香根草油乳液的体外释放特性。在这项工作中，Simulgel FL的浓度范围为重量比1%至3%，而香根草油的浓度有所不同：重量比为2.5%、5%和10%。发现Simulgel FL的合适浓度为重量比3%。为了进行比较，还制备了成分相似的水包油型香茅油乳液（香茅油重量比为10%）。香根草油和香茅油的混合物（重量比1:1）也用作活性成分。通过使用Simulgel FL，可以采用冷法（无需加热）制备乳液。稳定乳液的物理化学性质（外观、pH值、粘度）令人满意。所有制备的乳液均具有弱酸性pH值和假塑性流动。使用改良的Franz扩散池和合成膜，香根草油的释放速率相对低于香茅油。
