Jalkanen S, Reichert R A, Gallatin W M, Bargatze R F, Weissman I L, Butcher E C
Immunol Rev. 1986 Jun;91:39-60. doi: 10.1111/j.1600-065x.1986.tb01483.x.
The traffic of lymphocytes is controlled in part by the selective interaction of circulating lymphocytes with specialized high endothelial venule (HEV) cells at sites of lymphocyte exit from the blood. At least three independent receptor systems are responsible for controlling lymphocyte traffic to different lymphoid organs or to sites of inflammation: one mediates lymphocyte interaction with HEV in peripheral lymph nodes, another in mucosa-associated lymphoid tissues, and a third in inflamed synovium. The receptors mediating lymphocyte recognition of HEV in different organs appear to be structurally related yet antigenically and functionally distinct 90 kD glycoproteins. Receptors for lymph node HEV can function as mammalian lectins, and probably interact with specific carbohydrate ligands on high endothelial cells. Mouse and human homing receptors share both antigenic and structural features, indicating a high conservation of lymphocyte-endothelial recognition systems during evolution. They play an essential part in the immune process by controlling lymphocyte traffic during B- and T-cell differentiation, and by segregating effector cells derived from stimulation in different tissues, thus simultaneously increasing the efficiency of organ-specific immune responses and decreasing possibilities for autoimmune crossreactions. Homing receptors are also expressed by many mouse and human lymphoid neoplasms, and appear to play a role in lymphoma metastasis. Related if not identical receptors are expressed by other leukocyte types, including polymorphonuclear leukocytes, monocytes, and large granular lymphocytes (natural killer cells). Thus lymphocyte homing receptors are members of a family of glycoprotein receptors for endothelium that control the extravasation of lymphocytes as well as other leukocytes, and help regulate both non-specific and specific immune responses in vivo.
淋巴细胞的迁移部分受循环淋巴细胞与血液中淋巴细胞流出部位的特殊高内皮微静脉（HEV）细胞之间选择性相互作用的控制。至少有三种独立的受体系统负责控制淋巴细胞向不同淋巴器官或炎症部位的迁移：一种介导淋巴细胞与外周淋巴结中的HEV相互作用，另一种介导淋巴细胞与黏膜相关淋巴组织中的HEV相互作用，第三种介导淋巴细胞与炎症滑膜中的HEV相互作用。介导淋巴细胞识别不同器官中HEV的受体似乎是结构相关但抗原性和功能不同的90kD糖蛋白。淋巴结HEV的受体可作为哺乳动物凝集素发挥作用，可能与高内皮细胞上的特定碳水化合物配体相互作用。小鼠和人类归巢受体具有共同的抗原和结构特征，表明淋巴细胞 - 内皮识别系统在进化过程中高度保守。它们在免疫过程中起着至关重要的作用，通过在B细胞和T细胞分化过程中控制淋巴细胞迁移，并通过分离来自不同组织刺激的效应细胞，从而同时提高器官特异性免疫反应的效率并降低自身免疫交叉反应的可能性。归巢受体也在许多小鼠和人类淋巴肿瘤中表达，并且似乎在淋巴瘤转移中起作用。其他白细胞类型，包括多形核白细胞、单核细胞和大颗粒淋巴细胞（自然杀伤细胞）表达相关（如果不是相同）的受体。因此，淋巴细胞归巢受体是内皮糖蛋白受体家族的成员，其控制淋巴细胞以及其他白细胞的外渗，并有助于调节体内的非特异性和特异性免疫反应。
