Jalkanen S, Steere A C, Fox R I, Butcher E C
Science. 1986 Aug 1;233(4763):556-8. doi: 10.1126/science.3726548.
Lymphocytes are essential mediators of normal tissue inflammatory reactions and of pathologic tissue damage in, for example, rheumatoid arthritis and other autoimmune diseases. In a study of the mechanisms controlling lymphocyte entry into sites of inflammation from the blood, the function and specificity of lymphocyte-endothelial interactions were examined in inflamed joint tissue (synovium) from patients with rheumatoid arthritis. Synovial high endothelial venules (HEV) supported the binding of normal peripheral blood lymphocytes in vitro. The characteristics of this binding, which were similar to those of lymphocyte-HEV interactions controlling lymphocyte migration into organized lymphoid tissues, included a requirement for calcium ions, a dependence on metabolic activity, and a preferential adherence of circulating lymphocytes as opposed to immature thymocytes. However, the binding of lymphocytes to synovial HEV was not inhibited by a monoclonal antibody to lymphocyte receptors for lymph node HEV, and synovial HEV failed to bind either lymph node HEV-specific or mucosal HEV-specific B lymphoblastoid cells. The results suggest that a lymphocyte-endothelial cell recognition system that is distinct from such systems in organized lymphoid tissues directs the extravasation of normal lymphocytes as well as pathologically important effector cells into inflamed synovium.
淋巴细胞是正常组织炎症反应以及病理组织损伤（如类风湿关节炎和其他自身免疫性疾病）的重要介质。在一项关于控制淋巴细胞从血液进入炎症部位机制的研究中，研究人员在类风湿关节炎患者的炎症关节组织（滑膜）中检测了淋巴细胞与内皮细胞相互作用的功能和特异性。滑膜高内皮微静脉（HEV）在体外支持正常外周血淋巴细胞的结合。这种结合的特征与控制淋巴细胞迁移到有组织的淋巴组织中的淋巴细胞-HEV相互作用相似，包括对钙离子的需求、对代谢活性的依赖性以及循环淋巴细胞相对于未成熟胸腺细胞的优先黏附。然而，淋巴细胞与滑膜HEV的结合不受针对淋巴结HEV淋巴细胞受体的单克隆抗体的抑制，并且滑膜HEV无法结合淋巴结HEV特异性或黏膜HEV特异性B淋巴母细胞。结果表明，一种不同于有组织淋巴组织中的淋巴细胞-内皮细胞识别系统，可引导正常淋巴细胞以及具有病理重要性的效应细胞渗入炎症滑膜。
