Liu Xiaolan, Chen Xiaoyan, Yu Xinfang, Tao Yongguang, Bode Ann M, Dong Zigang, Cao Ya
Cancer Research Institute, Central South University, Changsha, Hunan 410078, China.
J Exp Clin Cancer Res. 2013 Nov 22;32(1):96. doi: 10.1186/1756-9966-32-96.
Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modification on miRNA is not adequately understood. EZH2 and HDACs were recently identified as critical histone modifiers of deregulated miRNAs in cancer and can be recruited to a miRNA promoter by transcription factors such as MYC. Because miRNAs can modulate epigenetic architecture and can be regulated by epigenetic alteration, they could reasonably play an important role in mediating the crosstalk between epigenetic regulators. The complicated network between miRNAs and epigenetic machineries underlies the epigenetic-miRNA regulatory pathway, which is important in monitoring gene expression profiles. Regulation of miRNAs by inducing epigenetic changes reveals promising avenues for the design of innovative strategies in the fight against human cancer.
与蛋白质编码基因类似，微小RNA（miRNA）也易受表观遗传调控。尽管已表明许多miRNA会受到DNA甲基化的影响，但组蛋白修饰对miRNA的调控机制尚未得到充分了解。EZH2和组蛋白去乙酰化酶（HDACs）最近被确定为癌症中失调miRNA的关键组蛋白修饰因子，并且可以被诸如MYC等转录因子招募至miRNA启动子。由于miRNA可以调节表观遗传结构并且可由表观遗传改变调控，它们在介导表观遗传调节因子之间的相互作用中可能发挥重要作用。miRNA与表观遗传机制之间的复杂网络构成了表观遗传-miRNA调控途径的基础，这一途径在监测基因表达谱方面很重要。通过诱导表观遗传变化来调控miRNA为设计对抗人类癌症的创新策略揭示了有前景的途径。
