Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Parkinson's Disease and Movement Disorders Unit, Neurology Clinic, Hospital Clinic Universitari, University of Barcelona, Barcelona, Spain.
Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S10-2. doi: 10.1016/S1353-8020(13)70005-1.
Dopaminergic neurons play a major role in controlling movement and behavior. In Parkinson's disease (PD), dopaminergic denervation is responsible for a number of motor and non-motor symptoms including tremor, rigidity and akinesia and as well apathy, impulsivity and other behavioral complications frequently reported in these patients. In this review, we will summarize the possible proposed dopaminergic mechanisms responsible for these complications in PD, focusing mainly on the role of this neurotransmitter in behavioral symptoms.
多巴胺能神经元在控制运动和行为方面起着重要作用。在帕金森病（PD）中，多巴胺能神经元丧失负责许多运动和非运动症状，包括震颤、僵硬和运动不能，以及这些患者经常报告的冷漠、冲动和其他行为并发症。在这篇综述中，我们将总结可能导致 PD 中这些并发症的多巴胺能机制，主要关注这种神经递质在行为症状中的作用。
