Department of Neurology, Donauspital/SMZ-Ost, Langobardenstrasse 122, 1220 Vienna, Austria.
J Neurol Sci. 2011 Nov 15;310(1-2):271-5. doi: 10.1016/j.jns.2011.07.012. Epub 2011 Aug 25.
Parkinson's disease (PD) is a progressive neurodegenerative condition which requires gradually increasing doses of dopaminergic substances for adequate motor control. Some vulnerable patients increase their doses beyond those required for motor control. This may result in a pattern of compulsive drug taking which may be associated with typical behavioural changes which define dopaminergic dysregulation syndrome (DDS). This is frequently associated with impulse control disorders and a specific behavioural abnormality involving prolonged repetitive tasks, called punding. The pathophysiology of DDS likely involves a number of factors, including genetic and personality related risk factors, habit formation resulting from unpleasant OFF symptoms, fronto-striatal dysfunction and a sensitisation process due to repeated dopaminergic stimulation. Management includes attempts to reduce the dopaminergic dose; specific treatment options are currently unknown. Early detection and prevention are therefore essential.
帕金森病（PD）是一种进行性神经退行性疾病，需要逐渐增加多巴胺能物质的剂量才能获得足够的运动控制。一些易受影响的患者会增加超出运动控制所需的剂量。这可能导致强迫性药物使用模式，可能与定义多巴胺能失调综合征（DDS）的典型行为变化有关。这通常与冲动控制障碍和一种特定的行为异常有关，涉及长时间重复的任务，称为“punding”。DDS 的病理生理学可能涉及多种因素，包括遗传和人格相关的危险因素、源于不愉快的“OFF”症状的习惯形成、额纹状体功能障碍以及由于反复多巴胺能刺激导致的敏化过程。治疗包括尝试降低多巴胺能剂量；目前还不知道具体的治疗选择。因此，早期发现和预防至关重要。
