Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford. OX3 9DU, UK.
Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S44-8. doi: 10.1016/S1353-8020(13)70013-0.
Modulations of beta oscillations (13-30 Hz) during normal motor control suggest that they may act to promote current motor set at the expense of new movements. These oscillations are greatly enhanced in Parkinson's disease (PD) and there is strong correlative evidence linking beta activity at rest and beta changes in response to treatment with bradykinesia and rigidity. Some evidence that this link may be mechanistically important or causal comes from studies in which either cortical or subcortical sites have been stimulated in the beta frequency range causing modest but significant slowing of movements. However, recent trials in which high frequency deep brain stimulation (DBS) has only been delivered during periods of elevated beta activity have demonstrated major clinical effects that even exceed those of standard continuous high frequency DBS. These studies suggest that beta activity may be both causally and quantitatively important in the motor impairment of PD, and demonstrate how improvements in the understanding of the pathophysiology of PD can lead to enhanced therapeutic interventions in this condition.
正常运动控制过程中β 脑波（13-30Hz）的调制表明，它们可能有助于促进当前运动，而抑制新的运动。帕金森病（PD）患者的β 脑波显著增强，且有大量相关证据表明，静息时β 活动与对运动迟缓及僵硬的治疗反应中的β 变化之间存在关联。一些证据表明，这种关联可能具有重要的机制或因果关系，这源于以下研究：在这些研究中，刺激皮质或皮质下部位以产生适度但显著的运动减速，频率在β 范围内。然而，最近的研究表明，在β 活动升高期间仅进行高频深部脑刺激（DBS），可产生重大的临床效果，甚至超过标准连续高频 DBS 的效果。这些研究表明，β 活动可能是 PD 运动障碍的重要原因和数量因素，并证明了对 PD 病理生理学的理解的提高如何能够促进该疾病的治疗干预。
