Department of Environmental Health, the University of Occupational and Environmental Health, Japan 1-1 Iseigaoka, Yahata-nishi, 807, Kitakyushu, Japan.
Biol Trace Elem Res. 1983 Aug;5(4-5):383-8. doi: 10.1007/BF02987222.
This study was performed in order to search for possible associations between cadmium (Cd) and other metals~ Cd, zinc (Zn), and copper (Cu) levels of renal cortex and liver samples obtained from 196 cancer cases and 198 noncancer controls were analyzed in eight regional institutes in Japan. Cd, Zn, and Cu concentrations in liver and renal cortex of the selected cancer cases were compared to the controls whose localities, age, and sex were matched with the cancer cases. The cancer cases clearly showed higher accumulations of Zn in liver and renal cortex than the noncancer group. Cd showed a similar tendency, but there was no statistical significance between case and control subjects. There was no marked difference in Cu accumulation between the pairs.The best fit regression curve of Zn to Cd on a molar basis in renal cortex was obtained. Curvilinear regression equations of Zn to Cd for both cancer and noncancer groups were drawn. From these two equations, the Zn level of the cancer cases was found to reach a maximum when the Cd level showed 1.4 mmol/kg (157 pxg/g), whereas Zn in the noncancer group peaked at 1.6 mmol/kg (180 Ixg/g) of Cd in renal cortex. This may suggest that excessive Cd accumulation deprives binding sites of Zn in renal cortex when both metals are saturated.
本研究旨在寻找镉（Cd）与其他金属之间可能存在的关联。从日本 8 个地区研究所采集的 196 例癌症病例和 198 例非癌症对照的肾脏皮质和肝脏样本中分析了 Cd、锌（Zn）和铜（Cu）的水平。将选定癌症病例的肝脏和肾脏皮质中的 Cd、Zn 和 Cu 浓度与局部、年龄和性别与癌症病例相匹配的非癌症组进行比较。癌症病例的肝脏和肾脏皮质中的 Zn 积累明显高于非癌症组。Cd 也呈现出类似的趋势，但病例和对照组之间没有统计学意义。两组之间 Cu 的积累没有明显差异。得出了肾脏皮质中 Zn 与 Cd 摩尔比的最佳拟合回归曲线。绘制了癌症和非癌症组 Zn 与 Cd 的曲线回归方程。从这两个方程可以发现，当 Cd 水平达到 1.4mmol/kg（157μg/g）时，癌症病例的 Zn 水平达到最大值，而非癌症组的 Zn 水平在肾脏皮质中的 Cd 达到 1.6mmol/kg（180μg/g）时达到最大值。这可能表明，当两种金属都饱和时，过量的 Cd 积累会剥夺肾脏皮质中 Zn 的结合位点。
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