Nomiyama K
Sci Total Environ. 1980 Apr;14(3):199-232. doi: 10.1016/0048-9697(80)90024-8.
Cadmium is a heavy metal, which is recently known to be hazardous to man. Cadmium workers have been observed to suffer from renal dysfunction and lung emphysema after long-term exposure to cadmium. However, since Itai-Itai disease, osteomalacia provoked in Toyama prefecture of Japan, was designated as a disease caused by cadmium in 1968, much attention has been paid to the health effects of residents in cadmium-polluted areas. The author described here recent progress and perspectives on cadmium health effect studies, cadmium analysis in biological samples; absorption, distribution and excretion of cadmium; health effects of residents in cadmium-polluted area; survey on the health status of Itai-Itai disease patients; beta 2-microglobulinuria; intestinal tract impairment and bone metabolism; effects on bone; effects on the liver; early diagnosis of cadmium effects; effects on future generations; carcinogenicity; critical concentration of cadmium; metallothionein; recommendations for future studies. One-hundred and sixty references are cited in this review.
镉是一种重金属，最近人们发现它对人体有害。长期接触镉的工人被观察到会出现肾功能障碍和肺气肿。然而，自1968年日本富山县发生的痛痛病（一种骨软化症）被认定为由镉引起的疾病以来，镉污染地区居民的健康影响受到了广泛关注。作者在此描述了镉健康影响研究的最新进展和前景、生物样品中的镉分析、镉的吸收、分布和排泄、镉污染地区居民的健康影响、痛痛病患者健康状况调查、β2-微球蛋白尿、肠道损伤和骨代谢、对骨骼的影响、对肝脏的影响、镉影响的早期诊断、对后代的影响、致癌性、镉的临界浓度、金属硫蛋白以及对未来研究的建议。本综述引用了160篇参考文献。
