博来霉素诱导的结节性肺纤维化伪装成转移性睾丸癌。

Bleomycin-induced nodular pulmonary fibrosis masquerading as metastatic testicular cancer.

作者信息

Dineen M K, Englander L S, Huben R P

出版信息

J Urol. 1986 Aug;136(2):473-5. doi: 10.1016/s0022-5347(17)44914-7.

Abstract

Bleomycin has become an important component of combination chemotherapy, particularly in the treatment of metastatic testis carcinoma. Pulmonary toxicity is a major risk and irreversible pulmonary fibrosis or even death may result from its use. Rarely diffuse fibrosis may lead to discrete nodularity mimicking pulmonary metastasis. We report such a case, and discuss the various clinical, radiographic and histopathological forms of bleomycin-induced pulmonary toxicity.

摘要

博来霉素已成为联合化疗的重要组成部分，尤其是在转移性睾丸癌的治疗中。肺部毒性是一个主要风险，使用该药可能导致不可逆的肺纤维化甚至死亡。罕见的弥漫性纤维化可能导致类似肺转移的散在结节。我们报告了这样一例病例，并讨论了博来霉素诱导的肺部毒性的各种临床、影像学和组织病理学表现形式。