血清高迁移率族蛋白B1升高与心房颤动患者的氧化应激有关。

Increased serum HMGB1 is related to oxidative stress in patients with atrial fibrillation.

作者信息

Wu Yongbo, Zhang Kai, Zhao Lin, Guo Jie, Hu Xiaorong, Chen Zhiqiang

机构信息

Department of Cardiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.

出版信息

J Int Med Res. 2013 Dec;41(6):1796-802. doi: 10.1177/0300060513503917.

DOI:10.1177/0300060513503917

PMID:24265331

Abstract

OBJECTIVE

To investigate the relationship between the serum concentration of high mobility group box 1 protein (HMGB1) and oxidative stress in patients with atrial fibrillation (AF).

METHODS

Patients with AF (paroxysmal or persistent) and matched control subjects were recruited. Serum HMGB1 concentration and malondialdehyde (MDA) and superoxide dismutase (SOD) activity were determined.

RESULTS

Serum hs-CRP and HMGB1 concentrations and MDA activity were significantly higher in patients with persistent AF (n = 33) or paroxysmal AF (n = 53) than in controls (n = 30). Serum SOD activity was significantly lower in both patient groups than in controls. In the patient group, HMGB1 concentration was significantly positively correlated with MDA activity (r = 0.535), and negatively correlated with SOD activity (r = -0.491). MDA, SOD, hs-CRP and HMGB1 were significant independent predictors of AF.

CONCLUSIONS

Increased oxidative stress may contribute to increased HMGB1 concentrations in patients with AF. Inhibition of oxidative stress may provide a potential therapeutic strategy for AF.

摘要

目的

探讨心房颤动（AF）患者血清高迁移率族蛋白B1（HMGB1）浓度与氧化应激之间的关系。

方法

招募阵发性或持续性房颤患者及匹配的对照对象。测定血清HMGB1浓度、丙二醛（MDA）和超氧化物歧化酶（SOD）活性。

结果

持续性房颤患者（n = 33）或阵发性房颤患者（n = 53）的血清高敏C反应蛋白（hs-CRP）、HMGB1浓度及MDA活性显著高于对照组（n = 30）。两组患者的血清SOD活性均显著低于对照组。在患者组中，HMGB1浓度与MDA活性显著正相关（r = 0.535），与SOD活性负相关（r = -0.491）。MDA、SOD、hs-CRP和HMGB1是房颤的显著独立预测因子。