Li Jin-Yi, He Yan, Ke Hong-Hong, Jin Yu, Jiang Zhi-Yuan, Zhong Guo-Qiang
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
Clin Cardiol. 2017 Feb;40(2):89-94. doi: 10.1002/clc.22633. Epub 2017 Feb 16.
Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AF patients remains unclear.
Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AF patients.
82 AF patients were compared to 30 control patients by using a case-control study design. Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were detected.
(1) Hs-CRP, IL-6, IL-8, TNF-α, MDA and ox-LDL were higher, and SOD was lower in AF patients than in control patients. Hs-CRP, MDA and ox-LDL were higher in permanent AF patients than in paroxysmal and persistent AF patients. (2) CsA of LSPV, RSPV, RIPV, LAA and LAV were statistically higher in AF patients than in control patients. CsA of RSPV, LSPV, LIPV and LAV were higher in permanent AF patients than in paroxysmal and persistent AF patients. (3) In the AF group, hs-CRP and TNF-α were positively correlated with LAV; MDA was positively correlated with CsA of LAA, LSPV and LAV; SOD was passively correlated with CsA of LAA and LAV; ox-LDL was positively correlated with CsA of LAA and LAV. Multivariate logistic regression analysis showed hs-CRP, ox-LDL, RSPV CsA, LIPV CsA and LAV were associated with AF.
Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were significantly increased in AF patients. Hs-CRP, ox-LDL, RSPV CsA, LIPV CsA and LAV were associated with AF persistence.
氧化应激和炎症过程与房颤的发病机制有关，但其与房颤患者左心房（LA）和肺静脉（PVs）大小的关系仍不清楚。
氧化应激和炎症过程与房颤患者的LA和PVs大小有关。
采用病例对照研究设计，将82例房颤患者与30例对照患者进行比较。检测氧化应激、炎症生物标志物以及LA和PVs的大小。
（1）房颤患者的超敏C反应蛋白（Hs-CRP）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）和氧化型低密度脂蛋白（ox-LDL）水平高于对照患者，而超氧化物歧化酶（SOD）水平低于对照患者。永久性房颤患者的Hs-CRP、MDA和ox-LDL水平高于阵发性和持续性房颤患者。（2）房颤患者的左肺上静脉（LSPV）、右肺上静脉（RSPV）、右肺下静脉（RIPV）、左心耳（LAA）和左心房容积（LAV）的周长面积比（CsA）在统计学上高于对照患者。永久性房颤患者的RSPV、LSPV、左肺下静脉（LIPV）和LAV的CsA高于阵发性和持续性房颤患者。（3）在房颤组中，hs-CRP和TNF-α与LAV呈正相关；MDA与LAA、LSPV和LAV的CsA呈正相关；SOD与LAA和LAV的CsA呈负相关；ox-LDL与LAA和LAV的CsA呈正相关。多因素逻辑回归分析显示，hs-CRP、ox-LDL、RSPV CsA、LIPV CsA和LAV与房颤有关。
房颤患者的氧化应激、炎症生物标志物以及LA和PVs的大小显著增加。Hs-CRP、ox-LDL、RSPV CsA、LIPV CsA和LAV与房颤的持续存在有关。
