Department of Clinical Microbiology, The Royal College of Surgeons in Ireland.
Clin Infect Dis. 2014 Mar;58(6):848-53. doi: 10.1093/cid/cit765. Epub 2013 Nov 21.
Innovative technologies have identified approaches to developing self-disinfecting surfaces or fabrics to minimize healthcare-associated infection (HCAI). These include altering the structure or surface to minimize the attachment of microbes or to delay the development of biofilm, using compounds that are activated in the presence of light to reduce the microbial burden, and incorporating a heavy metal such as silver or copper with intrinsic antimicrobial activity. Most technologies for surfaces and fabrics have been assessed in vitro and have been shown to reduce bacterial numbers by ≥2 logs. However, apart from copper -impregnated surfaces, there have been few trials in a clinical setting. Copper-impregnated surfaces result in reduced microbial surface counts on surfaces commonly found in clinical areas compared with controls, and 1 study has assessed HCAI and colonization rates. However, larger and better-designed studies are required to determine if these approaches augment current hygiene regimens, especially when these are optimally implemented.
创新技术已经确定了开发自消毒表面或织物的方法，以最大限度地减少与医疗保健相关的感染（HAI）。这些方法包括改变结构或表面以最小化微生物的附着或延迟生物膜的形成，使用在存在光的情况下被激活的化合物来减少微生物负担，并掺入具有内在抗菌活性的重金属，如银或铜。大多数用于表面和织物的技术已经在体外进行了评估，并已显示可使细菌数量减少≥2 个对数级。然而，除了铜浸渍表面外，在临床环境中进行的试验很少。与对照组相比，铜浸渍表面可使临床区域常见表面的微生物表面计数减少，并且有 1 项研究评估了 HAI 和定植率。然而，需要进行更大和设计更好的研究来确定这些方法是否增强了当前的卫生方案，特别是在最佳实施的情况下。
