Moon Chae Ho, Yoon Jong Ho, Kang Geon Wook, Lee Seong Hyeon, Baek Jeong Su, Kim Seo Yun, Kim Hye-Ryoun, Kim Cheol Hyeon
Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Tuberc Respir Dis (Seoul). 2013 Oct;75(4):165-9. doi: 10.4046/trd.2013.75.4.165. Epub 2013 Oct 29.
An inflammatory myofibroblastic tumor (IMT) is a rare disease entity reported to arise in various organs. It is thought to be a neoplastic or reactive inflammatory condition, controversially. The treatment of choice for myofibroblastic tumor is surgery, and recurrence is known to be rare. The optimal treatment method is not well-known for patients ineligible for surgery. We report a 47-year-old patient with aggressive recurrent IMT of the lungs. The patient had been admitted for an evaluation of back-pain two years after a complete resection of pulmonary IMT. Radiation therapy was performed for multiple bone recurrences, and the symptoms were improved. However the patient presented again with aggravated back-pain six months later. High-dose steroid and non-steroidal anti-inflammatory drugs were administered, but the disease progressed aggressively, resulting in spinal cord compression and metastasis to intra-abdominal organs. This is a very rare case of aggressively recurrent pulmonary IMT with multi-organ metastasis.
炎性肌成纤维细胞瘤（IMT）是一种据报道可发生于多种器官的罕见疾病实体。关于它究竟是肿瘤性疾病还是反应性炎症性疾病，存在争议。肌成纤维细胞瘤的首选治疗方法是手术，且已知复发罕见。对于不适合手术的患者，最佳治疗方法尚不清楚。我们报告一例47岁患有侵袭性复发性肺部IMT的患者。该患者在肺部IMT完全切除两年后因背痛入院评估。对多处骨复发进行了放射治疗，症状有所改善。然而，患者在六个月后再次出现背痛加重。给予了大剂量类固醇和非甾体类抗炎药，但疾病进展迅速，导致脊髓受压并转移至腹腔内器官。这是一例非常罕见的侵袭性复发性肺部IMT伴多器官转移的病例。
