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腰椎管炎性肌纤维母细胞瘤:一例报告并文献复习

Inflammatory myofibroblastic tumor of the lumbar spinal canal: A Case Report With Literature Review.

作者信息

Wang Shanshan, Chen Liang, Cao Zhang, Mao Xijin, Zhang Lin, Wang Bin

机构信息

Shandong Medical Imaging Research Institute, Shandong University Department of Radiology, Affiliated Hospital of Binzhou Medical University Medical Imaging Research Institute, Binzhou Medical University Department of Pathology, Affiliated Hospital of Binzhou Medical University, China.

出版信息

Medicine (Baltimore). 2017 Jun;96(26):e6488. doi: 10.1097/MD.0000000000006488.

DOI:10.1097/MD.0000000000006488
PMID:28658093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5500015/
Abstract

RATIONALE

Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor. IMT can arise in multiple anatomic locations. IMT of the lumbar spinal canal is exceptionally rare.

PATIENT CONCERNS

Here, we report the case of a 56-year-old male patient with an IMT who was in good health until 1 year prior to admission, when he began experiencing pain in both lower extremities and the lower back.

INTERVENTIONS

A space-occupying lesion in the lumbar canal was identified by magnetic resonance imaging and then surgically resected.

DIAGNOSES

Histopathological analysis of the lesion revealed a composition of mucous edema, inflammatory cells, collagenous fibers, and spindle cells that were diffuse and positive for smooth muscle actin and CD68; focal positive for vimentin and desmin; and negative for CD34 (marker of vascular endothelial cells), CD21, CD23, CD35, S-100, Epstein-Barr virus infection, Ki-67, and anaplastic lymphoma kinase. Thus, the diagnosis was an IMT of the lumbar canal.

OUTCOMES

In the spinal canal, IMT should be considered in the evaluation of tumors although it is a very rare diagnosis. It is a benign lesion, but it has potential for invasion and recurrence.

LESSONS

There are no characteristic imaging features of these tumors, but they can be addressed by complete surgical excision. Patients with these lesions should undergo frequent long-term follow-up to detect and address recurrence.

摘要

理论依据

炎性肌纤维母细胞瘤(IMT)是一种罕见的间叶性肿瘤。IMT可发生于多个解剖部位。腰椎管内的IMT极为罕见。

患者情况

在此,我们报告一例56岁男性IMT患者,入院前1年身体健康,之后开始出现双下肢及下背部疼痛。

干预措施

通过磁共振成像确定腰椎管内有占位性病变,随后进行手术切除。

诊断结果

病变的组织病理学分析显示,其由黏液水肿、炎性细胞、胶原纤维和梭形细胞组成,这些细胞弥漫分布,平滑肌肌动蛋白和CD68呈阳性;波形蛋白和结蛋白呈局灶性阳性;血管内皮细胞标志物CD34、CD21、CD23、CD35、S-100、EB病毒感染、Ki-67和间变性淋巴瘤激酶均为阴性。因此,诊断为腰椎管IMT。

治疗结果

在椎管内肿瘤的评估中,尽管IMT是一种非常罕见的诊断,但仍应予以考虑。它是一种良性病变,但有侵袭和复发的可能。

经验教训

这些肿瘤没有特征性的影像学表现,但可通过完整的手术切除来处理。患有这些病变的患者应进行频繁的长期随访,以检测和处理复发情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b202/5500015/92226db8eb21/medi-96-e6488-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b202/5500015/8f76748e8837/medi-96-e6488-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b202/5500015/b8676b9f0f6e/medi-96-e6488-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b202/5500015/92226db8eb21/medi-96-e6488-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b202/5500015/8f76748e8837/medi-96-e6488-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b202/5500015/b8676b9f0f6e/medi-96-e6488-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b202/5500015/92226db8eb21/medi-96-e6488-g003.jpg

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