Dai S, Ogle C W, Cho C H
Pharmacology. 1986;33(1):58-60. doi: 10.1159/000138201.
Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased gastric mucus synthesis. However, in vitro study showed that carbenoxolone significantly stimulated both gastric and duodenal mucus synthesis. It is suggested that carbenoxolone may also effectively increase mucus synthesis and probably accelerate ulcer healing in the duodenum if sufficient amounts can escape gastric absorption and reach this region.
采用阿尔辛蓝染色黏液并用氯化镁脱色的方法，发现给小鼠胃内给予甘珀酸，在显著增加胃黏液合成的剂量下，对十二指肠黏液合成没有显著影响。然而，体外研究表明，甘珀酸能显著刺激胃和十二指肠的黏液合成。提示如果有足够量的甘珀酸能逃过胃吸收并到达十二指肠区域，它也可能有效增加黏液合成并可能加速十二指肠溃疡的愈合。
